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Chromosomal aberrations in large Japanese field mice (Apodemus speciosus) captured near Fukushima Dai-ichi Nuclear Power Plant
https://repo.qst.go.jp/records/49002
https://repo.qst.go.jp/records/490028d1759a6-3338-4be6-b252-c6c23b039ff9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-15 | |||||
| タイトル | ||||||
| タイトル | Chromosomal aberrations in large Japanese field mice (Apodemus speciosus) captured near Fukushima Dai-ichi Nuclear Power Plant | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawagoshi, Taiki
× Kawagoshi, Taiki× Shiomi, Naoko× Takahashi, Hiroyuki× Watanabe, Yoshito× Fuma, Shoichi× Doi, Kazutaka× Kawaguchi, Isao× Aoki, Masanari× Kubota, Masahide× Furuhata, Yoshiaki× Shigemura, Yusaku× Mizoguchi, Masahiko× Yamada, Fumio× Tomozawa, Morihiko× H., Sakamoto Shinsuke× Yoshida, Satoshi× Kubota, Yoshihisa× 川越 大輝× 塩見 尚子× 渡辺 嘉人× 府馬 正一× 土居 主尚× 川口 勇生× 吉田 聡× 久保田 善久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Since the Fukushima Dai-ichi Nuclear Power Plant accident, radiation effects on nonhuman biota in the contaminated areas have been a major concern. Here, we analyzed the frequencies of chromosomal aberrations (translocations and dicentrics) in the splenic lymphocytes of large Japanese field mice (Apodemus speciosus) inhabiting Fukushima Prefecture. A. speciosus chromosomes 1, 2, and 5 were flow-sorted in order to develop A. speciosus chromosome-specific painting probes, and FISH (fluorescence in situ hybridization) was performed using these painting probes to detect the translocations and dicentrics. The average frequency of the translocations and dicentrics per cell in the heavily contaminated area was significantly higher than the frequencies in the case of the noncontaminated control area and the slightly and moderately contaminated areas, and this aberration frequency in individual mice tended to roughly increase with the estimated dose rates and accumulated doses. In all 4 sampling areas, the proportion of aberrations occurring in chromosome 2 was approximately >3 times higher than that in chromosomes 1 and 5, which suggests that A. speciosus chromosome 2 harbors a fragile site that is highly sensitive to chromosome breaks induced by cellular stress such as DNA replication. The elevated frequency of chromosomal aberrations in A. speciosus potentially resulting from the presence of a fragile site in chromosome 2 might make it challenging to observe the mild effect of chronic low-dose-rate irradiation on the induction of chromosomal aberrations in A. speciosus inhabiting the contaminated areas of Fukushima. | |||||
| 書誌情報 |
Environ. Sci. Technol. 巻 51, 号 8, p. 4632-4641, 発行日 2017-04 |
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| 出版者 | ||||||
| 出版者 | ACS Publicaitons | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28363014 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acs.est.6b06210 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://pubs.acs.org/doi/abs/10.1021/acs.est.6b06210 | |||||
| 関連名称 | http://pubs.acs.org/doi/abs/10.1021/acs.est.6b06210 | |||||
