@article{oai:repo.qst.go.jp:00049002,
 author = {Kawagoshi, Taiki and Shiomi, Naoko and Takahashi, Hiroyuki and Watanabe, Yoshito and Fuma, Shoichi and Doi, Kazutaka and Kawaguchi, Isao and Aoki, Masanari and Kubota, Masahide and Furuhata, Yoshiaki and Shigemura, Yusaku and Mizoguchi, Masahiko and Yamada, Fumio and Tomozawa, Morihiko and H., Sakamoto Shinsuke and Yoshida, Satoshi and Kubota, Yoshihisa and 川越 大輝 and 塩見 尚子 and 渡辺 嘉人 and 府馬 正一 and 土居 主尚 and 川口 勇生 and 吉田 聡 and 久保田 善久},
 issue = {8},
 journal = {Environ. Sci. Technol.},
 month = {Apr},
 note = {Since the Fukushima Dai-ichi Nuclear Power Plant accident, radiation effects on nonhuman biota in the contaminated areas have been a major concern. Here, we analyzed the frequencies of chromosomal aberrations (translocations and dicentrics) in the splenic lymphocytes of large Japanese field mice (Apodemus speciosus) inhabiting Fukushima Prefecture. A. speciosus chromosomes 1, 2, and 5 were flow-sorted in order to develop A. speciosus chromosome-specific painting probes, and FISH (fluorescence in situ hybridization) was performed using these painting probes to detect the translocations and dicentrics. The average frequency of the translocations and dicentrics per cell in the heavily contaminated area was significantly higher than the frequencies in the case of the noncontaminated control area and the slightly and moderately contaminated areas, and this aberration frequency in individual mice tended to roughly increase with the estimated dose rates and accumulated doses. In all 4 sampling areas, the proportion of aberrations occurring in chromosome 2 was approximately >3 times higher than that in chromosomes 1 and 5, which suggests that A. speciosus chromosome 2 harbors a fragile site that is highly sensitive to chromosome breaks induced by cellular stress such as DNA replication. The elevated frequency of chromosomal aberrations in A. speciosus potentially resulting from the presence of a fragile site in chromosome 2 might make it challenging to observe the mild effect of chronic low-dose-rate irradiation on the induction of chromosomal aberrations in A. speciosus inhabiting the contaminated areas of Fukushima.},
 pages = {4632--4641},
 title = {Chromosomal aberrations in large Japanese field mice (Apodemus speciosus) captured near Fukushima Dai-ichi Nuclear Power Plant},
 volume = {51},
 year = {2017}
}