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Biomathematical screening of amyloid radiotracers with clinical usefulness index
https://repo.qst.go.jp/records/48960
https://repo.qst.go.jp/records/48960f49946f3-754d-4bbd-a19c-3e3081284757
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-11 | |||||
| タイトル | ||||||
| タイトル | Biomathematical screening of amyloid radiotracers with clinical usefulness index | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nai, Ying-Hwey
× Nai, Ying-Hwey× Shidahara, Miho× Seki, Chie× Watabe, Hiroshi× 志田原 美保× 関 千江× 渡部 浩司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: To facilitate radiotracers’ development, a screening methodology using a biomathematical model and clinical usefulness index (CUI) was proposed to evaluate radiotracers’ diagnostic capabilities. Methods: A total of 31 amyloid positron emission tomography radiotracers were evaluated. A previously developed biomathematical model was used to simulate 1000 standardized uptake value ratios with population and noise simulations, which were used to determine the integrated receiver operating characteristics curve (Az), effect size (Es), and standardized uptake value ratio (Sr) of conditions-pairs of healthy control–mild cognitive impaired and mild cognitive impaired– Alzheimer’s disease. CUI was obtained from the product of averaged AzðAzÞ, EsðEsÞ, and SrðSrÞ. Results: The relationships of Az, Es, and Sr with CUI were different, suggesting that they assessed different radiotracer properties. The combination of Az, Es, and Sr complemented each other and resulted in CUI of 0.10 to 5.72, with clinically applied amyloid positron emission tomography radiotracers having CUI greater than 3.0. Discussion: The CUI rankings of clinically applied radiotracers were close to their reported clinical results, attesting to the applicability of the screening methodology. |
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| 書誌情報 |
Alzheimer’s & Dementia: Translational Research & Clinical Interventions 巻 3, 号 4, p. 542-552, 発行日 2017-09 |
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| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29124113 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.trci.2017.08.006 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671631/ | |||||
| 関連名称 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671631/ | |||||
