@article{oai:repo.qst.go.jp:00048960,
 author = {Nai, Ying-Hwey and Shidahara, Miho and Seki, Chie and Watabe, Hiroshi and 志田原 美保 and 関 千江 and 渡部 浩司},
 issue = {4},
 journal = {Alzheimer’s & Dementia: Translational Research & Clinical Interventions},
 month = {Sep},
 note = {Introduction: To facilitate radiotracers’ development, a screening methodology using a biomathematical
model and clinical usefulness index (CUI) was proposed to evaluate radiotracers’ diagnostic
capabilities.
Methods: A total of 31 amyloid positron emission tomography radiotracers were evaluated. A previously
developed biomathematical model was used to simulate 1000 standardized uptake value
ratios with population and noise simulations, which were used to determine the integrated receiver
operating characteristics curve (Az), effect size (Es), and standardized uptake value ratio (Sr) of
conditions-pairs of healthy control–mild cognitive impaired and mild cognitive impaired–
Alzheimer’s disease. CUI was obtained from the product of averaged AzðAzÞ, EsðEsÞ, and SrðSrÞ.
Results: The relationships of Az, Es, and Sr with CUI were different, suggesting that they assessed
different radiotracer properties. The combination of Az, Es, and Sr complemented each other and resulted
in CUI of 0.10 to 5.72, with clinically applied amyloid positron emission tomography radiotracers
having CUI greater than 3.0.
Discussion: The CUI rankings of clinically applied radiotracers were close to their reported clinical
results, attesting to the applicability of the screening methodology.},
 pages = {542--552},
 title = {Biomathematical screening of amyloid radiotracers with clinical usefulness index},
 volume = {3},
 year = {2017}
}