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Vitronection improves cell survival after radiation injury in human umbilical vein endothelial cells.
https://repo.qst.go.jp/records/48830
https://repo.qst.go.jp/records/48830a5e87970-012e-4367-b3e3-24a53729e959
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-01 | |||||
| タイトル | ||||||
| タイトル | Vitronection improves cell survival after radiation injury in human umbilical vein endothelial cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hazawa, Masaharu
× Hazawa, Masaharu× Yasuda, Takeshi× Noshiro, Katsuko× Saotome, Ai× Fukuzaki, Tomoko× Michikawa, Yuichi× Gotoh, Takaya× Tajima, Katsushi× 羽澤 勝治× 安田 武嗣× 野代 勝子× 早乙女 愛× 福崎 智子× 道川 祐市× 後藤 孝也× 田嶋 克史 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Vitronectin (VN) is a multi-functional protein involved in extracellular matrix (ECM)-cell binding through integrin receptors on the cell surface, which is an important environmental process for maintaining biological homeostasis. We investigated how VN affects the survival of endothelial cells after radiation damage. VN attenuated radiation-induced expression of p21, an inhibitor of cell cycle progression, and selectively inhibited Erk- and p38 MAPK-dependent p21 induction after radiation exposure through regulation of the activity of GSK-3b. VN also reduced the cleavage of caspase-3, thereby inhibiting radiation-induced apoptotic cell death. These results suggest that VN has important roles in cell survival after radiation damage. | |||||
| 書誌情報 |
FEBS Open Bio (Online Only URL:http://www.sciencedirect.com/science/journal/22115463) 巻 2, p. 334-338, 発行日 2012-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2211-5463 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | org/10.1016/j.fob.2012.10.002 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S2211546312000514 | |||||
| 関連名称 | http://www.sciencedirect.com/science/article/pii/S2211546312000514 | |||||
