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Washout effect in rabbit brain: in-beam PET measurements using 10C, 11C and 15O ion beams
https://repo.qst.go.jp/records/48798
https://repo.qst.go.jp/records/48798cbbc7bd8-4b46-4bb9-823c-ec541d1ac1ad
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-24 | |||||
| タイトル | ||||||
| タイトル | Washout effect in rabbit brain: in-beam PET measurements using 10C, 11C and 15O ion beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Toramatsu, Chie
× Toramatsu, Chie× Yoshida, Eiji× Wakizaka, Hidekatsu× Mohammadi, Akram× Ikoma, Yoko× Tashima, Hideaki× Nishikido, Fumihiko× Kitagawa, Atsushi× Karasawa, Kumiko× Hirano, Yoshiyuki× Yamaya, Taiga× 寅松 千枝× 吉田 英治× 脇坂 秀克× Ｍｏｈａｍｍａｄｉ Ａｋｒａｍ× 生駒 洋子× 田島 英朗× 錦戸 文彦× 北川 敦志× 唐澤 久美子× 平野 祥之× 山谷 泰賀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In particle therapy, in-beam positron emission tomography (PET)is expected to enable in situ noninvasive confirmation of the treatment delivery. For accurate range and dose verification or threedimensional (3D) volume imaging, however, correction of the biological washout effect in a living body is necessary. In this study, we measured the washout rate in a rabbit brain using the recently developed technology for oxygen beam radiation as well as carbon ion beam radiation. To measure components of washout, three radionuclides, 10C, 11C and 15O, which were generated as secondary beams in the Heavy Ion Medical Accelerator in Chiba (HIMAC), were irradiated on the rabbit brain under two conditions, live and dead. In-beam data were acquired by our whole body dual-ring OpenPET, which enables 3D in-beam imaging. Regions of interests(ROIs)were set as a 3D positron distribution and the time activity curves(TACs) of the irradiated field were acquired. We obtained the washout rate for those conditions based on multiple component model analysis. A difference between washout speed in 11C ions and the 15O ions was observed. The observed medium and slow biological decay rates of 11C ions in rabbit brain were 0.30 min−1 and 0.004 min−1 , respectively. Those values were consistent with the previous rabbit study results acquired by other imaging modalities, such as the pair of positron cameras or our single-ring small animal OpenPET prototype. The observed medium and slow biological decay rates of 15O ions were 0.72 min−1 and 0.024 min−1 , respectively, which were faster than those of the 11C ion. Also, the medium biological decay rate of 15O ions was close to the washout rate in cerebral blood flow(CBF) measurements by dynamic PET with 15O-labeled water. These results should help to establish an accurate washout correction model. |
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| 書誌情報 |
Biomedical Physics & Engineering Express 巻 4, 号 3, p. 035001, 発行日 2018-03 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/2057-1976/aaade7 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1088/2057-1976/aaade7 | |||||
| 関連名称 | https://doi.org/10.1088/2057-1976/aaade7 | |||||
