@article{oai:repo.qst.go.jp:00048798,
 author = {Toramatsu, Chie and Yoshida, Eiji and Wakizaka, Hidekatsu and Mohammadi, Akram and Ikoma, Yoko and Tashima, Hideaki and Nishikido, Fumihiko and Kitagawa, Atsushi and Karasawa, Kumiko and Hirano, Yoshiyuki and Yamaya, Taiga and 寅松 千枝 and 吉田 英治 and 脇坂 秀克 and Ｍｏｈａｍｍａｄｉ Ａｋｒａｍ and 生駒 洋子 and 田島 英朗 and 錦戸 文彦 and 北川 敦志 and 唐澤 久美子 and 平野 祥之 and 山谷 泰賀},
 issue = {3},
 journal = {Biomedical Physics & Engineering Express},
 month = {Mar},
 note = {In particle therapy, in-beam positron emission tomography (PET)is expected to enable in situ noninvasive confirmation of the treatment delivery. For accurate range and dose verification or threedimensional (3D) volume imaging, however, correction of the biological washout effect in a living body is necessary. In this study, we measured the washout rate in a rabbit brain using the recently
developed technology for oxygen beam radiation as well as carbon ion beam radiation. To measure components of washout, three radionuclides, 10C, 11C and 15O, which were generated as secondary beams in the Heavy Ion Medical Accelerator in Chiba (HIMAC), were irradiated on the rabbit brain under two conditions, live and dead. In-beam data were acquired by our whole body dual-ring OpenPET, which enables 3D in-beam imaging. Regions of interests(ROIs)were set as a 3D positron distribution and the time activity curves(TACs) of the irradiated field were acquired. We obtained the
washout rate for those conditions based on multiple component model analysis. A difference between washout speed in 11C ions and the 15O ions was observed. The observed medium and slow biological decay rates of 11C ions in rabbit brain were 0.30 min−1 and 0.004 min−1 , respectively. Those values
were consistent with the previous rabbit study results acquired by other imaging modalities, such as the pair of positron cameras or our single-ring small animal OpenPET prototype. The observed medium and slow biological decay rates of 15O ions were 0.72 min−1 and 0.024 min−1 , respectively, which were faster than those of the 11C ion. Also, the medium biological decay rate of 15O ions was close to the washout rate in cerebral blood flow(CBF) measurements by dynamic PET with 15O-labeled water. These results should help to establish an accurate washout correction model.},
 title = {Washout effect in rabbit brain: in-beam PET measurements using 10C, 11C and 15O ion beams},
 volume = {4},
 year = {2018}
}