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A New Approach for Quantifying Radio-Biological Effects using the Time Course of Mouse Leg Contracture
https://repo.qst.go.jp/records/48797
https://repo.qst.go.jp/records/4879729bc6b25-5b6f-49af-82d0-6048b492301b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-15 | |||||
| タイトル | ||||||
| タイトル | A New Approach for Quantifying Radio-Biological Effects using the Time Course of Mouse Leg Contracture | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ueno, Megumi
× Ueno, Megumi× Nakanishi, Ikuo× Ken-ichiro, Matsumoto× Megumi, Ueno× Ikuo, Nakanishi× Kenichiro, Matsumoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A digitization approach to the time course of radiation-induced mouse leg contracture was proposed for quantifying the radiation effect on an individual living mouse. The shortening of the mouse leg length can be easily measured with a caliper/ruler to offer a very simple digitalized index of the radiation effect. Left hind legs of mice were irradiated with single dose of 32 Gy of 290 MeV carbon-ion beam using 0, 50, or 117 mm binary filter (BF). The right legs were used as a control. The lengths of both hind legs of the mice were measured using a digital caliper before irradiation and every week after irradiation. The degree of leg contracture, ΔSt, at the time point t was estimated by subtraction of the left irradiated leg length from the right control leg length. Equation 1 was fitted on the daily time course of ΔSt, and two parameters, ΔSmax and Ts, were estimated. ΔSt = ΔSmax × ( 1 – exp(t / Ts) )[1] where ΔSmax is the maximum degree of leg contracture, and Ts is time of leg contracture. The effect of carbon-ion irradiation on a living mouse was quantified by ΔSmax and Ts of the leg contracture, and then compared to that of X-rays. By 32 Gy irradiation, ΔSmax was largest for the BF117 experiment, followed by X-ray ~ BF50 > BF0. Ts was shortest for the BF50 experiment, while other irradiation conditions give similar Ts. A logarithmic function was successfully repurposed for the evaluation of radio-biological response. |
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| 書誌情報 |
Biological & Pharmaceutical Bulletin 巻 41, 号 3, p. 368-373, 発行日 2018-03 |
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| 出版者 | ||||||
| 出版者 | 日本薬学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29491213 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/bpb.b17-00689 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/bpb/41/3/41_b17-00689/_article | |||||
