{"created":"2023-05-15T14:37:49.233476+00:00","id":48797,"links":{},"metadata":{"_buckets":{"deposit":"80ed8a6c-7e21-43dc-8f75-7f2fd274c1c1"},"_deposit":{"created_by":1,"id":"48797","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48797"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048797","sets":["1"]},"author_link":["1024722","1024723","1024720","1024721","1024725","1024724"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"373","bibliographicPageStart":"368","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Biological & Pharmaceutical Bulletin"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A digitization approach to the time course of radiation-induced mouse leg contracture was proposed for quantifying the radiation effect on an individual living mouse. The shortening of the mouse leg length can be easily measured with a caliper/ruler to offer a very simple digitalized index of the radiation effect. Left hind legs of mice were irradiated with single dose of 32 Gy of 290 MeV carbon-ion beam using 0, 50, or 117 mm binary filter (BF). The right legs were used as a control. The lengths of both hind legs of the mice were measured using a digital caliper before irradiation and every week after irradiation. The degree of leg contracture, ΔSt, at the time point t was estimated by subtraction of the left irradiated leg length from the right control leg length. Equation 1 was fitted on the daily time course of ΔSt, and two parameters, ΔSmax and Ts, were estimated.\nΔSt = ΔSmax × ( 1 – exp(t / Ts) )[1]\nwhere ΔSmax is the maximum degree of leg contracture, and Ts is time of leg contracture. The effect of carbon-ion irradiation on a living mouse was quantified by ΔSmax and Ts of the leg contracture, and then compared to that of X-rays. By 32 Gy irradiation, ΔSmax was largest for the BF117 experiment, followed by X-ray ~ BF50 > BF0. Ts was shortest for the BF50 experiment, while other irradiation conditions give similar Ts. A logarithmic function was successfully repurposed for the evaluation of radio-biological response.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29491213","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.b17-00689","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/bpb/41/3/41_b17-00689/_article","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueno, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"1024720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"1024721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ken-ichiro, Matsumoto"}],"nameIdentifiers":[{"nameIdentifier":"1024722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Megumi, Ueno","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikuo, Nakanishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenichiro, Matsumoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024725","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A New Approach for Quantifying Radio-Biological Effects using the Time Course of Mouse Leg Contracture","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A New Approach for Quantifying Radio-Biological Effects using the Time Course of Mouse Leg Contracture"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-08-15"},"publish_date":"2017-08-15","publish_status":"0","recid":"48797","relation_version_is_last":true,"title":["A New Approach for Quantifying Radio-Biological Effects using the Time Course of Mouse Leg Contracture"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:05:17.643837+00:00"}