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Repeated photon and C-ion irradiations in vivo have different impact on alteration of tumor characteristics
https://repo.qst.go.jp/records/48784
https://repo.qst.go.jp/records/48784063459ab-286c-493b-b5bb-660c1280c7d2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-23 | |||||
| タイトル | ||||||
| タイトル | Repeated photon and C-ion irradiations in vivo have different impact on alteration of tumor characteristics | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sato, Katsutoshi
× Sato, Katsutoshi× Nitta, Nobuhiro× Aoki, Ichio× Imai, Takashi× Shimokawa, Takashi× 佐藤 克俊× 新田 展大× 青木 伊知男× 今井 高志× 下川 卓志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Precise characterization of tumor recurrence and regrowth after radiotherapy are important for prognostic understanding of the therapeutic effect. Here, we established a novel in vivo mouse model for evaluating the characteristics of regrown tumor after repeated photon and carbon ion (C-ion) irradiations. The results showed that tumor growth rate, lung metastasis, shortening of the survival of the tumor-bearing mice, and tumor microvessel formation were promoted 2- to 3-fold, and expression of angiogenic and metastatic genes increased 1.5- to 15-fold in regrown tumors after repeated photon irradiations, whereas repeated C-ion irradiations did not alter these characteristics. Interestingly, both repeated photon and C-ion irradiations did not generate radioresistance, which is generally acquired for in vitro treatment. Our results demonstrated that the repetition of photon, and not C-ion, irradiations in vivo alter the characteristics of the regrown tumor, making it more aggressive without acquisition of radioresistance. | |||||
| 書誌情報 |
Scientific Reports 巻 8, 号 1, p. 1458, 発行日 2018-01 |
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| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29362374 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-018-19422-x | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-018-19422-x | |||||
| 関連名称 | https://www.nature.com/articles/s41598-018-19422-x | |||||
