@article{oai:repo.qst.go.jp:00048784,
 author = {Sato, Katsutoshi and Nitta, Nobuhiro and Aoki, Ichio and Imai, Takashi and Shimokawa, Takashi and 佐藤 克俊 and 新田 展大 and 青木 伊知男 and 今井 高志 and 下川 卓志},
 issue = {1},
 journal = {Scientific Reports},
 month = {Jan},
 note = {Precise characterization of tumor recurrence and regrowth after radiotherapy are important for prognostic understanding of the therapeutic effect. Here, we established a novel in vivo mouse model for evaluating the characteristics of regrown tumor after repeated photon and carbon ion (C-ion) irradiations. The results showed that tumor growth rate, lung metastasis, shortening of the survival of the tumor-bearing mice, and tumor microvessel formation were promoted 2- to 3-fold, and expression of angiogenic and metastatic genes increased 1.5- to 15-fold in regrown tumors after repeated photon irradiations, whereas repeated C-ion irradiations did not alter these characteristics. Interestingly, both repeated photon and C-ion irradiations did not generate radioresistance, which is generally acquired for in vitro treatment. Our results demonstrated that the repetition of photon, and not C-ion, irradiations in vivo alter the characteristics of the regrown tumor, making it more aggressive without acquisition of radioresistance.},
 title = {Repeated photon and C-ion irradiations in vivo have different impact on alteration of tumor characteristics},
 volume = {8},
 year = {2018}
}