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18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia
https://repo.qst.go.jp/records/48767
https://repo.qst.go.jp/records/487679c0b9ae7-a5c3-4718-bb9c-8cca58c5f9ab
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-20 | |||||
| タイトル | ||||||
| タイトル | 18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Higashi, Tatsuya
× Higashi, Tatsuya× Nishii, Ryuichi× Kagawa, Shinya× Kishibe, Yoshihiko× Takahashi, Masaaki× Okina, Tomoko× Suzuki, Norio× Hasegawa, Hiroshi× Nagahama, Yasuhiro× Ishizu, Koichi× Oishi, Naoya× Kimura, Hiroyuki× Watanabe, Hiroyuki× Ono, Masahiro× Saji, Hideo× Yamauchi, Hiroshi× 東 達也× 西井 龍一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Recently, we developed a benzofuran derivative for the imaging of β- amyloid plaques, 5-(5-(2-(2-(2-18F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- Nmethylpyridin- 2-amine (18F-FPYBF-2) (Ono et al., 2011). The aim of this study was to assess the feasibility of 18F-FPYBF-2 as an amyloid imaging PET tracer in a first clinical study with healthy volunteers and patients with various dementia and in comparative dual tracer study using 11C-Pittsburgh Compound B (11C-PiB). Methods: Sixty-one healthy volunteers (age: 53.7+/-13.1 y.o.; 19 male and 42 female; age range 24-79) and fifty-five patients with suspected dementia (Alzheimer's Disease (AD); early AD: n=19 and moderate stage AD: n=8, other dementia: n=9, Mild Cognitive Impairment; MCI: n=16, cognitively normal: n=3) for first clinical study underwent static head PET/CT scan using 18F-FPYBF-2 at 50-70min after injection. Thirteen volunteers and fourteen patients also underwent dynamic PET scan at 0- 50min at the same instant. Sixteen subjects (volunteers: n=5, patients with dementia: n=11) (age: 66.3+/-14.2 y.o.; 10 male and 6 female) were evaluated for comparative study (50-70min after injection) using 18F-FPYBF-2 and 11C-PiB on separate days, respectively. Quantitative analysis of mean cortical uptake was calculated using Mean Cortical Index of SUVR (Standardized Uptake Value Ratio) based on the established method for 11C-PiB analysis using cerebellar cortex as control. Results: Studies with healthy volunteers showed that 18F-FPYBF-2 uptake was mainly observed in cerebral white matter and that average Mean Cortical Index at 50-70min was low and stable (1.066+/-0.069) basically independent from age or gender. In patients with AD, 18F-FPYBF-2 uptake was observed both in cerebral white and gray matter and Mean Cortical Index was significantly higher (early AD: 1.288+/-0.134, moderate AD: 1.342+/-0.191) than those of volunteers and other dementia (1.018+/- 0.057). In comparative study, the results of 18F-FPYBF-2 PET/CT were comparable with those of 11C-PiB, and the Mean Cortical Index (18F-FPYBF-2: 1.173+/-0.215; 11C-PiB: 1.435+/-0.474) showed direct proportional relationship with each other (p<0.0001). Conclusions: Our first clinical study suggest that 18F-FPYBF-2 is a useful PET tracer for the evaluation of β-amyloid deposition and that quantitative analysis of Mean Cortical Index of SUVR is a reliable diagnostic tool for the diagnosis of AD. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 32, 発行日 2018-01 |
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| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1864-6433 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-018-1236-1 | |||||
