{"created":"2023-05-15T14:37:47.893452+00:00","id":48767,"links":{},"metadata":{"_buckets":{"deposit":"65cb3b00-4fae-4bb1-b046-58be5a38a243"},"_deposit":{"created_by":1,"id":"48767","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48767"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048767","sets":["1"]},"author_link":["490970","490973","490980","490982","490983","490981","490976","490968","490975","490984","490971","490978","490969","490967","490972","490979","490977","490974"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Annals of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Recently, we developed a benzofuran derivative for the imaging of β-\namyloid plaques, 5-(5-(2-(2-(2-18F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- Nmethylpyridin-\n2-amine (18F-FPYBF-2) (Ono et al., 2011). The aim of this study was to\nassess the feasibility of 18F-FPYBF-2 as an amyloid imaging PET tracer in a first\nclinical study with healthy volunteers and patients with various dementia and in\ncomparative dual tracer study using 11C-Pittsburgh Compound B (11C-PiB).\nMethods: Sixty-one healthy volunteers (age: 53.7+/-13.1 y.o.; 19 male and 42 female;\nage range 24-79) and fifty-five patients with suspected dementia (Alzheimer's Disease\n(AD); early AD: n=19 and moderate stage AD: n=8, other dementia: n=9, Mild\nCognitive Impairment; MCI: n=16, cognitively normal: n=3) for first clinical study\nunderwent static head PET/CT scan using 18F-FPYBF-2 at 50-70min after injection.\nThirteen volunteers and fourteen patients also underwent dynamic PET scan at 0-\n50min at the same instant. Sixteen subjects (volunteers: n=5, patients with dementia:\nn=11) (age: 66.3+/-14.2 y.o.; 10 male and 6 female) were evaluated for comparative\nstudy (50-70min after injection) using 18F-FPYBF-2 and 11C-PiB on separate days,\nrespectively. Quantitative analysis of mean cortical uptake was calculated using Mean\nCortical Index of SUVR (Standardized Uptake Value Ratio) based on the established\nmethod for 11C-PiB analysis using cerebellar cortex as control.\nResults: Studies with healthy volunteers showed that 18F-FPYBF-2 uptake was mainly\nobserved in cerebral white matter and that average Mean Cortical Index at 50-70min\nwas low and stable (1.066+/-0.069) basically independent from age or gender. In\npatients with AD, 18F-FPYBF-2 uptake was observed both in cerebral white and gray\nmatter and Mean Cortical Index was significantly higher (early AD: 1.288+/-0.134,\nmoderate AD: 1.342+/-0.191) than those of volunteers and other dementia (1.018+/-\n0.057). In comparative study, the results of 18F-FPYBF-2 PET/CT were comparable\nwith those of 11C-PiB, and the Mean Cortical Index (18F-FPYBF-2: 1.173+/-0.215;\n11C-PiB: 1.435+/-0.474) showed direct proportional relationship with each other\n(p<0.0001).\nConclusions: Our first clinical study suggest that 18F-FPYBF-2 is a useful PET tracer\nfor the evaluation of β-amyloid deposition and that quantitative analysis of Mean\nCortical Index of SUVR is a reliable diagnostic tool for the diagnosis of AD.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Japan"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12149-018-1236-1","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1864-6433","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"490967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishii, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"490968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kagawa, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"490969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishibe, Yoshihiko"}],"nameIdentifiers":[{"nameIdentifier":"490970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"490971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okina, Tomoko"}],"nameIdentifiers":[{"nameIdentifier":"490972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Norio"}],"nameIdentifiers":[{"nameIdentifier":"490973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"490974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagahama, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"490975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishizu, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"490976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oishi, Naoya"}],"nameIdentifiers":[{"nameIdentifier":"490977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"490978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"490979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"490980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saji, Hideo"}],"nameIdentifiers":[{"nameIdentifier":"490981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamauchi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"490982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"490983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西井 龍一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"490984","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-20"},"publish_date":"2018-04-20","publish_status":"0","recid":"48767","relation_version_is_last":true,"title":["18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:30.344717+00:00"}