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Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease.
https://repo.qst.go.jp/records/48660
https://repo.qst.go.jp/records/48660f9887694-d739-496c-b93a-ba9fe6f74b71
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-04 | |||||
| タイトル | ||||||
| タイトル | Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirano, Shigeki
× Hirano, Shigeki× Shinoto, Hitoshi× Shimada, Hitoshi× Ota, Tsuneyoshi× Sato, Koichi× Tanaka, Noriko× Ming-Rong, Zhang× Higuchi, Makoto× Fukushi, Kiyoshi× Irie, Toshiaki× Kuwabara, Satoshi× Suhara, Tetsuya× Hirano, Shigeki× Shinoto, Hitoshi× Shimada, Hitoshi× Ota, Tsuneyoshi× Ming-Rong, Zhang× Higuchi, Makoto× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by chronic progressive cognitive decline and displays underlying brain cholinergic dysfunction, providing a rationale for treatment with cholinomimetic medication. The clinical presentations and courses of AD patients may differ by age of onset. Objective: The objective of the present study was to illustrate the regional differences of brain acetylcholinesterase (AChE) activity as quantified by N-[11C]methylpiperidinyl-4-acetate ([11C]MP4A) and PET using parametric whole brain analysis and clarify those differences as a function of age. Methods: 22 early onset AD (EOAD) with age at onset under 65, the remaining 26 as late onset AD (LOAD), and 16 healthy controls (HC) were enrolled. Voxel-based AChE activity estimation of [11C]MP4A PET images was conducted by arterial input and unconstrained nonlinear least-squares method with subsequent parametrical analyses. Statistical threshold was set as Family Wise Error corrected, p-value < 0.05 on cluster-level and cluster extent over 30 voxels. Results: Voxel-based group comparison showed that, compared to HC, both EOAD and LOAD showed cortical AChE decrement in parietal, temporal, and occipital cortices, with wider and stringent cortical involvement in the EOAD group, most prominently demonstrated in the temporal region. Therewas no significant correlation between age and regional cerebral AChE activity except for a small left superior temporal region in the AD group (Brodmann’s area 22, Zmax = 5.13, 396 voxels), whereas no significant cluster was found in the HC counterpart. Conclusion: Difference in cortical cholinergic dysfunction between EOAD and LOAD may shed some light on the cholinomimetic drug efficacy in AD. Keywords: Acetylcholinesterase, age, Alzheimer’s |
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| 書誌情報 |
Journal of Alzheimer’s Disease 巻 62, 号 4, p. 1539-1548, 発行日 2018-03 |
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| 出版者 | ||||||
| 出版者 | IOS Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1387-2877 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29562505 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3233/JAD-170749 | |||||
