{"created":"2023-05-15T14:37:43.222089+00:00","id":48660,"links":{},"metadata":{"_buckets":{"deposit":"62827c3c-a9e5-40c2-bb3e-a16173885825"},"_deposit":{"created_by":1,"id":"48660","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48660"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048660","sets":["1"]},"author_link":["865128","865127","865119","865121","865135","865125","865129","865118","865117","865133","865124","865126","865131","865132","865123","865120","865130","865134","865122"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1548","bibliographicPageStart":"1539","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Journal of Alzheimer’s Disease"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by chronic progressive cognitive\ndecline and displays underlying brain cholinergic dysfunction, providing a rationale for treatment with cholinomimetic\nmedication. The clinical presentations and courses of AD patients may differ by age of onset.\nObjective: The objective of the present study was to illustrate the regional differences of brain acetylcholinesterase (AChE)\nactivity as quantified by N-[11C]methylpiperidinyl-4-acetate ([11C]MP4A) and PET using parametric whole brain analysis\nand clarify those differences as a function of age.\nMethods: 22 early onset AD (EOAD) with age at onset under 65, the remaining 26 as late onset AD (LOAD), and 16 healthy\ncontrols (HC) were enrolled. Voxel-based AChE activity estimation of [11C]MP4A PET images was conducted by arterial\ninput and unconstrained nonlinear least-squares method with subsequent parametrical analyses. Statistical threshold was set\nas Family Wise Error corrected, p-value < 0.05 on cluster-level and cluster extent over 30 voxels.\nResults: Voxel-based group comparison showed that, compared to HC, both EOAD and LOAD showed cortical AChE\ndecrement in parietal, temporal, and occipital cortices, with wider and stringent cortical involvement in the EOAD group,\nmost prominently demonstrated in the temporal region. Therewas no significant correlation between age and regional cerebral\nAChE activity except for a small left superior temporal region in the AD group (Brodmann’s area 22, Zmax = 5.13, 396 voxels),\nwhereas no significant cluster was found in the HC counterpart.\nConclusion: Difference in cortical cholinergic dysfunction between EOAD and LOAD may shed some light on the cholinomimetic\ndrug efficacy in AD.\nKeywords: Acetylcholinesterase, age, Alzheimer’s","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IOS Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29562505","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3233/JAD-170749","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1387-2877","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirano, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"865117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"865118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"865119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ota, Tsuneyoshi"}],"nameIdentifiers":[{"nameIdentifier":"865120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"865121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"865122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"865123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"865124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"865125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"865126","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"865127","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"865128","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865129","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865130","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865131","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ota, Tsuneyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865132","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865133","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865134","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865135","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-04"},"publish_date":"2018-04-04","publish_status":"0","recid":"48660","relation_version_is_last":true,"title":["Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:59:08.602068+00:00"}