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Covalent modifications of histone H3K9 promote binding of CHD3
https://repo.qst.go.jp/records/48620
https://repo.qst.go.jp/records/48620e9a0c0db-2620-4e21-b218-40ad21f51c07
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-23 | |||||
| タイトル | ||||||
| タイトル | Covalent modifications of histone H3K9 promote binding of CHD3 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
A., H. Tencer
× A., H. Tencer× K.L., Cox× D., Luo× J., B. Bridgers× J, Lyu× X., Wang× J., K. Sims× T.M., Weaver× H., F. Allen× Y., Zhang× J., Gatchalian× M., Darcy× M., Gibson× J., Ikebe× W., Li× P.A., Wade× J.J., Hayes× B., D. Strahl× H., Kono× M, .G. Poirier× C., A. Musselman× T., G. Kutateladze× ルオ ディ× 河野 秀俊 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3) whose functional significance is not well established. Here, we show that CHD3 co-localizes with the other NuRD subunits, including HDAC1, near the H3K9ac-enriched promoters of the NuRD target genes. The tandem PHD fingers of CHD3 bind histone H3 tails and posttranslational modifications that increase hydrophobicity of H3K9-methylation or acetylation (H3K9me3 or H3K9ac)-enhance this interaction. Binding of CHD3 PHDs promotes H3K9Cme3-nucleosome unwrapping in vitro and perturbs the pericentric heterochromatin structure in vivo. Methylation or acetylation of H3K9 uniquely alleviates the intra-nucleosomal interaction of histone H3 tails, increasing H3K9 accessibility. Collectively, our data suggest that the targeting of covalently modified H3K9 by CHD3 might be essential in diverse functions of NuRD. | |||||
| 書誌情報 |
Cell Reports 巻 21, 号 2, p. 455-465, 発行日 2017-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2211-1247 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29020631 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.celrep.2017.09.054 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/29020631 | |||||
| 関連名称 | https://www.ncbi.nlm.nih.gov/pubmed/29020631 | |||||
