{"created":"2023-05-15T14:37:41.455763+00:00","id":48620,"links":{},"metadata":{"_buckets":{"deposit":"92cc0781-04e9-471e-ba95-a83751424978"},"_deposit":{"created_by":1,"id":"48620","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48620"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048620","sets":["1"]},"author_link":["488936","488943","488949","488942","488955","488944","488934","488937","488950","488945","488948","488935","488933","488932","488953","488947","488938","488941","488939","488940","488951","488952","488946","488954"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"465","bibliographicPageStart":"455","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Cell Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3) whose functional significance is not well established. Here, we show that CHD3 co-localizes with the other NuRD subunits, including HDAC1, near the H3K9ac-enriched promoters of the NuRD target genes. The tandem PHD fingers of CHD3 bind histone H3 tails and posttranslational modifications that increase hydrophobicity of H3K9-methylation or acetylation (H3K9me3 or H3K9ac)-enhance this interaction. Binding of CHD3 PHDs promotes H3K9Cme3-nucleosome unwrapping in vitro and perturbs the pericentric heterochromatin structure in vivo. Methylation or acetylation of H3K9 uniquely alleviates the intra-nucleosomal interaction of histone H3 tails, increasing H3K9 accessibility. Collectively, our data suggest that the targeting of covalently modified H3K9 by CHD3 might be essential in diverse functions of NuRD.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29020631","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.celrep.2017.09.054","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.ncbi.nlm.nih.gov/pubmed/29020631"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/29020631","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2211-1247","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"A., H. 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Strahl"}],"nameIdentifiers":[{"nameIdentifier":"488949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"H., Kono"}],"nameIdentifiers":[{"nameIdentifier":"488950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"M, .G. Poirier"}],"nameIdentifiers":[{"nameIdentifier":"488951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"C., A. Musselman"}],"nameIdentifiers":[{"nameIdentifier":"488952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"T., G. Kutateladze"}],"nameIdentifiers":[{"nameIdentifier":"488953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ルオ ディ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河野 秀俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488955","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Covalent modifications of histone H3K9 promote binding of CHD3","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Covalent modifications of histone H3K9 promote binding of CHD3"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-23"},"publish_date":"2018-03-23","publish_status":"0","recid":"48620","relation_version_is_last":true,"title":["Covalent modifications of histone H3K9 promote binding of CHD3"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:26:09.116041+00:00"}