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Temperature-Dependent Free Radical Reaction in Water
https://repo.qst.go.jp/records/48608
https://repo.qst.go.jp/records/48608a2f4bf74-ac0c-4fbf-9eaf-5bc1a3ad23b2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-22 | |||||
| タイトル | ||||||
| タイトル | Temperature-Dependent Free Radical Reaction in Water | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Ken-ichiro
× Matsumoto, Ken-ichiro× Nyuui, Minako× Kamibayashi, Masato× Ozawa, Toshihiko× Nakanishi, Ikuo× Anzai, Kazunori× 松本 謙一郎× 乳井 美奈子× 上林 將人× 小澤 俊彦× 中西 郁夫× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Temperature-dependent free radical reactions were investigated using nitroxyl radicals as redox probes. Reactions of two types of nitroxyl radicals, TEMPOL (4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl) and carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl), were tested in this paper. Heating a solution containing a nitroxyl radical and a reduced form of glutathione (GSH) caused temperature-dependent decay of electron paramagnetic resonance (EPR) signal intensity of the nitroxyl radical. Heating a solution of the corresponding hydroxylamine form of the nitroxyl radical showed EPR signal recovery. The GSH-dependent reduction of nitroxyl radicals at 70[Deg]C was suppressed by antioxidants, spin trapping agents, and/or bubbling N2 gas, although heating carbamoyl-PROXYL with GSH showed temporarily enhanced signal decay by bubbling N2 gas. Since SOD could restrict the GSH-dependent EPR signal decay of TEMPOL, O2- is related with this reaction. O2- was probably generated from dissolved oxygen in the reaction mixture. Oxidation of the hydroxylamines at 70[Deg]C was also suppressed by bubbling N2 gas. Heating a solution of spin trapping agent, DMPO (5,5-dimethyl-1-pyrroline-N-oxide) showed a temperature-dependent increase of the EPR signal of the hydroxyl radical adduct of DMPO. Synthesis of hydroxyl radical adduct of DMPO at 70[Deg]C was suppressed by antioxidants and/or bubbling N2 gas. The results suggested that heating an aqueous solution containing oxygen can generate reactive oxygen species, mainly O2-. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 50, 号 1, p. 40-46, 発行日 2011-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.10-145 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/jcbn/50/1/50_10-145/_article | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/jcbn/50/1/50_10-145/_article | |||||
