WEKO3
アイテム
Comparisons of EPR imaging and T(1)-weighted MRI for efficient imaging of nitroxyl contrast agents.
https://repo.qst.go.jp/records/48599
https://repo.qst.go.jp/records/48599a30798b2-4e2c-4fac-b62b-fc4ce02117f3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-20 | |||||
| タイトル | ||||||
| タイトル | Comparisons of EPR imaging and T(1)-weighted MRI for efficient imaging of nitroxyl contrast agents. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Ken-ichiro
× Matsumoto, Ken-ichiro× Narazaki, Michiko× Ikehira, Hiroo× Anzai, Kazunori× Ikota, Nobuo× 松本 謙一郎× 楢崎 美智子× 池平 博夫× 安西 和紀× 伊古田 暢夫 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The resolution and signal to noise ratio of EPR imaging and T1-weighted MRI were compared using an identical phantom. Several solutions of nitroxyl contrast agents with different EPR spectral shapes were tested. The feasibility of T1-weighted MRI to detect nitroxyl contrast agents was described. T1-weighted MRI can detect nitroxyl contrast agents with a complicated EPR spectrum easier and quicker; however, T1-weighted MRI has less quantitative ability especially for lipophilic nitroxyl contrast agents, because T1-relaxivity, i.e. accessibility to water, is affected by the hydrophilic/hydrophobic micro-environment of a nitroxyl contrast agent. The less quantitative ability of T1-weighted MRI may not be a disadvantage of redox imaging, which obtains reduction rate of a nitroxyl contrast. Therefore, T1-weighted MRI has a great advantage to check the pharmacokinetics of newly modified and/or designed nitroxyl contrast agents. 2007 Elsevier Inc. All rights reserved. | |||||
| 書誌情報 |
Journal of Magnetic Resonance 巻 187, 号 1, p. 155-162, 発行日 2007-06 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1090-7807 | |||||
