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Carbon-ion radiotherapy for non-small cell lung cancer with interstitial lung disease: a retrospective analysis
https://repo.qst.go.jp/records/48579
https://repo.qst.go.jp/records/48579c0251877-1829-4745-b181-aff6e28ab0b9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-16 | |||||
| タイトル | ||||||
| タイトル | Carbon-ion radiotherapy for non-small cell lung cancer with interstitial lung disease: a retrospective analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakajima, Mio
× Nakajima, Mio× Yamamoto, Naoyoshi× Hayashi, Kazuhiko× Karube, Masataka× Ebner, Daniel× Takahashi, Wataru× Anzai, Makoto× Tsushima, Kenji× Tada, Yuji× Tatsumi, Koichiro× Miyamoto, Tadaaki× Tsuji, Hiroshi× Fujisawa, Takehiko× Kamada, Tadashi× 中嶋 美緒× 山本 直敬× 林 和彦× 軽部 雅崇× エブナー ダニエル× 高橋 渉× 安西 誠× 多田 裕司× 巽 浩一郎× 宮本 忠昭× 辻 比呂志× 藤澤 武彦× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background \nLung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for lung cancer patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause acute exacerbation of ILD. This study evaluated the toxicity and efficacy of carbon ion radiotherapy (CIRT) in patients with non-small cell lung cancer (NSCLC) and ILD. \n Methods \nBetween June 2004 and November 2014, 29 patients diagnosed with NSCLC and ILD were treated with CIRT. No patient was eligible for curative surgery or conventional radiotherapy secondary to ILD. Owing to prior symptomology, radiation pneumonitis (RP) and symptom progression pre- and post-treatment were evaluated. The relationships between RP and clinical factors were investigated. \n Results \nTwenty-eight men and one woman, aged 62 to 90 years old, were followed for 2.7–77.1 months (median: 22.8 months). Single-grade symptomatic progression (grade 2–3) was observed in 4 patients, while 1 patient experiencedtwo-grade progression. Two patients experienced radiation-induced acute exacerbation. Local control at 3 years was 63.3% (72.2% for stage I disease); survival at 3 years was 46.3% (57.2% for stage I disease). Eighteen patients had died by the time of this writing, 10 of lung cancer progression. Radiation pneumonitis post-treatment progression correlated with dosimetric factors of the lungs (V5, V10) and a low pre-treatment serum surfactant protein-D. \n Conclusions \nWe found that CIRT may be useful as a low-risk, curative option for NSCLC patients with ILD, a population that is typically ineligible for conventional therapy. The DVH analysis showed that minimizing the low-dose region is important for reducing the risk of severe RP. |
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| 書誌情報 |
Radiation Oncology 巻 12, 号 1, p. 144-1-144-9, 発行日 2017-09 |
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| 出版者 | ||||||
| 出版者 | Biomed Central | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1748-717X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28865463 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s13014-017-0881-1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1186/s13014-017-0881-1 | |||||
| 関連名称 | https://doi.org/10.1186/s13014-017-0881-1 | |||||
