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High-Throughput Screening of Radioprotectors Using Rat Thymocytes
https://repo.qst.go.jp/records/48530
https://repo.qst.go.jp/records/48530c2973271-df1b-4aee-967c-8efa0dc1ac75
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-20 | |||||
| タイトル | ||||||
| タイトル | High-Throughput Screening of Radioprotectors Using Rat Thymocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sekine, Emiko
× Sekine, Emiko× Nakanishi, Ikuo× Shimokawa, Takashi× Ueno, Megumi× Matsumoto, Ken-ichiro× Murakami, Takeshi× 関根 絵美子× 中西 郁夫× 下川 卓志× 上野 恵美× 松本 謙一郎× 村上 健 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We invented a high-throughput screening method for the examination of radioprotective activity of chemical compounds using rat thymocytes. X-irradiation of the rat thymocytes induced apoptosis, leading to a significant cell shrinkage, which could be easily detected and directly quantified by the flow cytometry analysis. The protective effect of some natural antioxidants against radiation induced apoptosis in the rat thymocytes, as well as their toxicities without X-irradiation, was successfully evaluated using this method. This method provides a powerful tool to develop novel radioprotectors without toxicity and can also be widely used to estimate other oxidative stress except for radiation. | |||||
| 書誌情報 |
Analytical Chemistry 巻 85, 号 16, p. 7650-7653, 発行日 2013-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0003-2700 | |||||
