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Evaluation of the Sonosensitizing Activities of 5-Aminolevulinic Acid and Sn(IV) Chlorin e6 in Tumor-Bearing Chick Embryos
https://repo.qst.go.jp/records/48528
https://repo.qst.go.jp/records/48528789ae443-d960-4a9e-a2fe-431df8071cb5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-20 | |||||
| タイトル | ||||||
| タイトル | Evaluation of the Sonosensitizing Activities of 5-Aminolevulinic Acid and Sn(IV) Chlorin e6 in Tumor-Bearing Chick Embryos | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Uto, Yoshihiro
× Uto, Yoshihiro× Tamatani, Dai× Mizuki, Yusuke× Endo, Yoshio× Nakanishi, Ikuo× Ohkubo, Kei× Fukuzumi, Shunichi× Ishizuka, Masahiro× Tanaka, Tohru× Kuchiike, Daisuke× Kubo, Kentaro× Inui, Toshio× Hori, Hitoshi× 中西 郁夫× 大久保 敬 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Recently, 5-aminolevulinic acid (5-ALA), precursors of protoporphyrin IX (PpIX), and Sn(IV) chlorine e6 (SnCe6) have been proposed as possible sonosensitizers for sonodynamic therapy of cancer. Therefore, we evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in vivo by using the EMT6/KU tumor-bearing chick embryos. Results: The concentration of PpIX in tumor and liver tissues and serum increased in a time-dependent manner after the i.v. administration of 5-ALA; PpIX concentrations reached their peak level after 5-7 h. The concentration of SnCe6 reached its maximum value in the tumor tissue and serum immediately after i.v. administration. The combined treatment of 5-ALA or SnCe6 with ultrasound irradiation showed a significant anti tumor effect towards EMT6/KU solid tumors. Conclusion: We evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in a chick embryo model and found that 5-ALA might be more suitable as a sonosensitizer than SnCe6. |
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| 書誌情報 |
Anticancer Research 巻 34, 号 8, p. 4583-4588, 発行日 2014-07 |
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| 出版者 | ||||||
| 出版者 | International Institute of Anticancer Research (IIAR) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0250-7005 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25075103 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ar.iiarjournals.org/content/34/8/4583.abstract | |||||
| 関連名称 | http://ar.iiarjournals.org/content/34/8/4583.abstract | |||||
