@article{oai:repo.qst.go.jp:00048528,
 author = {Uto, Yoshihiro and Tamatani, Dai and Mizuki, Yusuke and Endo, Yoshio and Nakanishi, Ikuo and Ohkubo, Kei and Fukuzumi, Shunichi and Ishizuka, Masahiro and Tanaka, Tohru and Kuchiike, Daisuke and Kubo, Kentaro and Inui, Toshio and Hori, Hitoshi and 中西 郁夫 and 大久保 敬},
 issue = {8},
 journal = {Anticancer Research},
 month = {Jul},
 note = {Background: Recently, 5-aminolevulinic acid (5-ALA), precursors of protoporphyrin IX (PpIX), and Sn(IV) chlorine e6 (SnCe6) have been proposed as possible sonosensitizers for sonodynamic therapy of cancer.  Therefore, we evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in vivo by using the EMT6/KU tumor-bearing chick embryos.
Results: The concentration of PpIX in tumor and liver tissues and serum increased in a time-dependent manner after the i.v. administration of 5-ALA; PpIX concentrations reached their peak level after 5-7 h.  The concentration of SnCe6 reached its maximum value in the tumor tissue and serum immediately after i.v. administration.  The combined treatment of 5-ALA or SnCe6 with ultrasound irradiation showed a significant anti tumor effect towards EMT6/KU solid tumors.
Conclusion: We evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in a chick embryo model and found that 5-ALA might be more suitable as a sonosensitizer than SnCe6.},
 pages = {4583--4588},
 title = {Evaluation of the Sonosensitizing Activities of 5-Aminolevulinic Acid and Sn(IV) Chlorin e6 in Tumor-Bearing Chick Embryos},
 volume = {34},
 year = {2014}
}