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Continuous wave EPR oximetric imaging at 300 MHz using radiofrequency power saturation effects
https://repo.qst.go.jp/records/48491
https://repo.qst.go.jp/records/48491828daaf8-a114-445c-82d3-8e445f9d25b5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-14 | |||||
| タイトル | ||||||
| タイトル | Continuous wave EPR oximetric imaging at 300 MHz using radiofrequency power saturation effects | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hama, Yukihiro
× Hama, Yukihiro× Matsumoto, Ken-ichiro× Murugesan, Ramachandran× Subramanian, Sankaran× Devasahayam, Nallathamby× W., Koscielniak Janusz× Hyodo, Fuminori× A., Cook John× B., Mitchell James× C., Krishna Murali× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A novel continuous wave (CW), radiofrequency (RF), electron paramagnetic resonance (EPR) oximetric imaging technique is proposed, based on the influence of oxygen concentration on the RF power saturation of the EPR resonance. A linear relationship is demonstrated between the partial oxygen pressure (pO2) and the normalized signal intensity (IN), defined as, IN = (IHP - ILP) / ILP, where ILP and IHP refer to signal intensities at low (PL) and high (PH) RF power levels, respectively. A formula for the determination of pO2, derived on the basis of the experimental results, reliably estimated various oxygen concentrations in a five-tube phantom. This new technique was time-efficient and also avoided the missing angle problem associated with conventional spectral-spatial CW EPR oximetric imaging. In vivo power saturation oximetric imaging in a tumor bearing mouse clearly depicted the hypoxic foci within the tumor. | |||||
| 書誌情報 |
Antioxidants & Redox Signaling 巻 9, 号 10, p. 1709-1716, 発行日 2007-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1523-0864 | |||||
