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Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation
https://repo.qst.go.jp/records/48488
https://repo.qst.go.jp/records/4848815af75c3-78bf-4155-9f58-bcb665bdd22e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-15 | |||||
| タイトル | ||||||
| タイトル | Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Okajo, Aya× Nagata, Katsura× DeGraff, William× Nyuui, Minako× Ueno, Megumi× Nakanishi, Ikuo× Ozawa, Toshihiko× Mitchell, James× Krishna, Murali× Yamamoto, Haruhiko× Endo, Kazutoyo× Anzai, Kazunori× Kenichiro, Matsumoto× Minako, Nyui× Megumi, Ueno× Ikuo, Nakanishi× Toshihiko, Ozawa× Kazunori, Anzai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Quantitative detection of free radical reactions induced by low linear-energy-transfer (LET) irradiation in an aqueous solution was attempted using nitroxyl radicals. The stability and reactivity of reaction mixutres containing a nitroxyl radical and a hydrogen donor, i.e., glutathione (GSH), nicotinamide adenine dinucleotide (NADH), or nicotinamide adenine dinucleotide phosphate (NADPH), were tested. X-band electron paramagnetic resonance (EPR) measurements of several reaction mixtures were perfomed to find a suitable preparation to quantitatively detect free radical reactions produced by low LET irradiation. The EPR signal intensity of nitroxyl radicals was decreased by low LET irradiation when a hydrogen donor coexisted in the reaction mixture. The combination of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (4-hydroxy-TEMPO, known as TEMPOL) and GSH was most preferable among other preparatins tested in this paper, because of the sensitivity and irreversible reaction. The extent of the free radical reaction, i.e., formation of reactive oxygen species, in the reaction mixure depended on the radiation energy when an identical dose was given. | |||||
| 書誌情報 |
Biological & Pharmaceutical Bulletin 巻 32, 号 4, p. 542-547, 発行日 2009-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
