@article{oai:repo.qst.go.jp:00048488,
 author = {Ken-ichiro, Matsumoto and Okajo, Aya and Nagata, Katsura and DeGraff, William and Nyuui, Minako and Ueno, Megumi and Nakanishi, Ikuo and Ozawa, Toshihiko and Mitchell, James and Krishna, Murali and Yamamoto, Haruhiko and Endo, Kazutoyo and Anzai, Kazunori and Kenichiro, Matsumoto and Minako, Nyui and Megumi, Ueno and Ikuo, Nakanishi and Toshihiko, Ozawa and Kazunori, Anzai},
 issue = {4},
 journal = {Biological & Pharmaceutical Bulletin},
 month = {Apr},
 note = {Quantitative detection of free radical reactions induced by low linear-energy-transfer (LET) irradiation in an aqueous solution was attempted using nitroxyl radicals. The stability and reactivity of reaction mixutres containing a nitroxyl radical and a hydrogen donor, i.e., glutathione (GSH), nicotinamide adenine dinucleotide (NADH), or nicotinamide adenine dinucleotide phosphate (NADPH), were tested. X-band electron paramagnetic resonance (EPR) measurements of several reaction mixtures were perfomed to find a suitable preparation to quantitatively detect free radical reactions produced by low LET irradiation. The EPR signal intensity of nitroxyl radicals was decreased by low LET irradiation when a hydrogen donor coexisted in the reaction mixture. The combination of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (4-hydroxy-TEMPO, known as TEMPOL) and GSH was most preferable among other preparatins tested in this paper, because of the sensitivity and irreversible reaction. The extent of the free radical reaction, i.e., formation of reactive oxygen species, in the reaction mixure depended on the radiation energy when an identical dose was given.},
 pages = {542--547},
 title = {Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation},
 volume = {32},
 year = {2009}
}