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Equivalency of the Quality of Sub-lethal Lesions after Photons and High-Linear Energy Transfer Ion Beams
https://repo.qst.go.jp/records/48455
https://repo.qst.go.jp/records/48455062191ec-fa27-42ca-b720-5fc8d5bb717e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-06 | |||||
| タイトル | ||||||
| タイトル | Equivalency of the Quality of Sub-lethal Lesions after Photons and High-Linear Energy Transfer Ion Beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Furusawa, Yoshiya
× Furusawa, Yoshiya× Nakano-Aoki, Mizuho× Matsumoto, Yoshitaka× Hirayama, Ryoichi× Kobayashi, Alisa× Konishi, Teruaki× 古澤 佳也× 青木 瑞穂× 松本 孔貴× 平山 亮一× 小林 亜利紗× 小西 輝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To make the quality of the sublethal damage (SLD) after high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Accelerator in Chiba facility. The cells were kept at room temperature and then exposed to a secondary test dose of X-rays. Based on the repair kinetics study, the surviving fraction of cells quickly increased with the repair time, and reached a plateau in 2-3 h, even when cells had received priming monoenergetic high-LET beams or spread-out Bragg peak beams as well as X-ray. The shapes of the cell survival curves from the secondary test X-ray, after repair of the damage caused by the high-LET radiations, were similar to those obtained from cells exposed to primary X-ray only. Complete SLD repairs were observed even when the LET of the primary ion beams was very high. These results suggest that the SLD caused by high-LET radiations was repaired well, and likewise the damage caused by the X-ray. In cells where the ion beam had made a direct hit to the core region in an ion track, lethal damage to the domain was produced, resulting in cell death. On the other hand, in domains that had received a glancing hit at the low-LET penumbra region, the SLD produced was completely repaired. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 58, 号 6, p. 803-808, 発行日 2017-06 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28992250 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrx030 | |||||
