Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers

Abstract
\nBACKGROUND/AIM:
\nTo evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy.
\nPATIENTS AND METHODS:
\nData regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions.
\nRESULTS:
\nSixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively.
\nCONCLUSION:
\nRe-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients.

書誌情報

Anticancer Research

巻 37, 号 10, p. 5577-5583, 発行日 2017-10

ISSN

収録物識別子タイプ

ISSN

収録物識別子

0250-7005

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PMID

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Ver.1

2023-05-15 23:28:06.014993

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