@article{oai:repo.qst.go.jp:00048438, author = {Shiba, Shintaro and Okonogi, Noriyuki and Kato, Shingo and Wakatsuki, Masaru and Kobayashi, Daijiro and Kiyohara, Hiroki and Ohno, Tatsuya and Karasawa, Kumiko and Nakano, Takashi and Kamada, Tadashi and 柴 慎太郎 and 小此木 範之 and 加藤 眞吾 and 若月 優 and 小林 大二郎 and 清原 浩樹 and 大野 達也 and 唐澤 久美子 and 中野 隆史 and 鎌田 正}, issue = {10}, journal = {Anticancer Research}, month = {Oct}, note = {Abstract \nBACKGROUND/AIM: \nTo evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy. \nPATIENTS AND METHODS: \nData regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions. \nRESULTS: \nSixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively. \nCONCLUSION: \nRe-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients.}, pages = {5577--5583}, title = {Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers}, volume = {37}, year = {2017} }