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Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis.
https://repo.qst.go.jp/records/48420
https://repo.qst.go.jp/records/48420ea51e8a1-7cbe-44f8-b26d-433e4f2d0e3b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-01-11 | |||||
| タイトル | ||||||
| タイトル | Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Ninomiya, Yasuharu× Tanaka, Kaoru× Maruyama, Kouichi× Vares, Guillaume× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru× 王 冰× 二宮 康晴× 田中 薫× 丸山 耕一× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 笠井 清美× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: Adaptive response (AR) of low linear energy transfer (LET) irradiations for protection against teratogenesis induced by high LET irradiations is not well documented. In this study, induction of AR by X-rays against teratogenesis induced by accelerated heavy ions was examined in fetal mice. METHODS: Irradiations of pregnant C57BL/6J mice were performed by delivering a priming low-dose from X-rays at 0.05 Gy or 0.30 Gy on gestation day 11 followed one day later by a challenge high-dose from either X-rays or accelerated heavy ions. Mono-energetic beams of carbon, neon, silicon and iron with the LET values of about 15, 30, 55, and 200 keV/micrometer respectively were examined. Significant suppression of teratogenic effects (fetal death, malformation of live fetuses, or low body weight) was used as the endpoint for judgment of a successful AR induction. RESULTS: Existence of AR induced by low-LET X-rays against teratogenic effect induced by high-LET accelerated heavy ions was demonstrated. The priming low-dose of X-rays significantly reduced the occurrence of prenatal fetal death, malformation and/or low body weight induced by the challenge high-dose from either X-rays or accelerated heavy ions of carbon, neon or silicon but not iron particles. CONCLUSIONS: Successful AR induction appears to be a radiation quality event, depending on the LET value and/or the particle species of the challenge irradiations. These findings would provide a new insight into the study on radiation-induced AR in utero. | |||||
| 書誌情報 |
Birth Defects Research. Part B, Developmental and Reproductive Toxicology 巻 95, 号 6, p. 379-385, 発行日 2012-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1542-9733 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/bdrb.21027 | |||||
