@article{oai:repo.qst.go.jp:00048420,
 author = {Bing, Wang and Ninomiya, Yasuharu and Tanaka, Kaoru and Maruyama, Kouichi and Vares, Guillaume and Eguchi-Kasai, Kiyomi and Nenoi, Mitsuru and 王 冰 and 二宮 康晴 and 田中 薫 and 丸山 耕一 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 笠井 清美 and 根井 充},
 issue = {6},
 journal = {Birth Defects Research. Part B, Developmental and Reproductive Toxicology},
 month = {Dec},
 note = {BACKGROUND: Adaptive response (AR) of low linear energy transfer (LET) irradiations for protection against teratogenesis induced by high LET irradiations is not well documented. In this study, induction of AR by X-rays against teratogenesis induced by accelerated heavy ions was examined in fetal mice. METHODS: Irradiations of pregnant C57BL/6J mice were performed by delivering a priming low-dose from X-rays at 0.05 Gy or 0.30 Gy on gestation day 11 followed one day later by a challenge high-dose from either X-rays or accelerated heavy ions. Mono-energetic beams of carbon, neon, silicon and iron with the LET values of about 15, 30, 55, and 200 keV/micrometer respectively were examined. Significant suppression of teratogenic effects (fetal death, malformation of live fetuses, or low body weight) was used as the endpoint for judgment of a successful AR induction. RESULTS: Existence of AR induced by low-LET X-rays against teratogenic effect induced by high-LET accelerated heavy ions was demonstrated. The priming low-dose of X-rays significantly reduced the occurrence of prenatal fetal death, malformation and/or low body weight induced by the challenge high-dose from either X-rays or accelerated heavy ions of carbon, neon or silicon but not iron particles. CONCLUSIONS: Successful AR induction appears to be a radiation quality event, depending on the LET value and/or the particle species of the challenge irradiations. These findings would provide a new insight into the study on radiation-induced AR in utero.},
 pages = {379--385},
 title = {Adaptive Response of Low Linear Energy Transfer X-Rays for Protection Against High Linear Energy Transfer Accelerated Heavy Ion-Induced Teratogenesis.},
 volume = {95},
 year = {2012}
}