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Age and gender effects of 11C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants.
https://repo.qst.go.jp/records/48419
https://repo.qst.go.jp/records/484192497b86a-38a6-4ac9-b3a3-8f77363709d4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-01-04 | |||||
| タイトル | ||||||
| タイトル | Age and gender effects of 11C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakata, Muneyuki
× Sakata, Muneyuki× Toyohara, Jun× Ishibashi, Kenji× Wagatsuma, Kei× Ishii, Kenji× Zhang, Ming-Rong× Ishiwata, Kiichi× 豊原 潤× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined possible age- and gender-related changes in binding of the selective antagonist N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3- thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM) to metabotropic glutamate receptor type 1 (mGluR1) in healthy human brains. Dynamic 11C-ITMM positron emission tomography scans (90 min) with serial arterial blood sampling were performed in 15 young and 24 older healthy adult volunteers. The total distribution volume (VT) of several brain regions was estimated with two-tissue compartment model analysis. The VTs of the cerebellar cortex, parietal cortex, putamen, amygdala, and hippocampus in older adult participants were significantly higher than in young participants. The age-related VT increase was only observed in male participants. Our data suggest that an age-dependent increase in mGluR1 availability in several brain regions may exist predominantly in males. |
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| 書誌情報 |
Neurobiology of aging 巻 55, p. 72-77, 発行日 2017-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0197-4580 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28431287 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neurobiolaging.2017.03.022 | |||||
