{"created":"2023-05-15T14:37:32.198344+00:00","id":48419,"links":{},"metadata":{"_buckets":{"deposit":"23446aef-128e-4626-a85c-66e89d253b2d"},"_deposit":{"created_by":1,"id":"48419","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48419"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048419","sets":["1"]},"author_link":["486729","486726","486722","486728","486725","486727","486723","486724","486730"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"77","bibliographicPageStart":"72","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Neurobiology of aging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined possible age- and gender-related changes in binding\nof the selective antagonist N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-\nthiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM) to metabotropic\nglutamate receptor type 1 (mGluR1) in healthy human brains.\nDynamic 11C-ITMM positron emission tomography scans (90 min) with serial\narterial blood sampling were performed in 15 young and 24 older healthy\nadult volunteers. The total distribution volume (VT) of several brain\nregions was estimated with two-tissue compartment model analysis.\nThe VTs of the cerebellar cortex, parietal cortex, putamen, amygdala, and\nhippocampus in older adult participants were significantly higher than in\nyoung participants. The age-related VT increase was only observed in male\nparticipants.\nOur data suggest that an age-dependent increase in mGluR1 availability in\nseveral brain regions may exist predominantly in males.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28431287","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neurobiolaging.2017.03.022","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0197-4580","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"486722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyohara, Jun"}],"nameIdentifiers":[{"nameIdentifier":"486723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishibashi, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"486724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wagatsuma, Kei"}],"nameIdentifiers":[{"nameIdentifier":"486725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"486726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"486727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"486728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"豊原 潤","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486730","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Age and gender effects of 11C-ITMM binding to metabotropic  glutamate receptor type 1 in healthy human participants.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Age and gender effects of 11C-ITMM binding to metabotropic  glutamate receptor type 1 in healthy human participants."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-04"},"publish_date":"2018-01-04","publish_status":"0","recid":"48419","relation_version_is_last":true,"title":["Age and gender effects of 11C-ITMM binding to metabotropic  glutamate receptor type 1 in healthy human participants."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:28:19.618504+00:00"}