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  1. 原著論文

Comparison of expression profiles of several fibroblast growth factor receptors in the mouse jejunum: suggestive evidence for a differential radioprotective effect among major FGF family members and the potency of FGF1

https://repo.qst.go.jp/records/48385
https://repo.qst.go.jp/records/48385
7f7f6fb6-8486-4c86-a1bd-f8a3df2cfd72
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-11-22
タイトル
タイトル Comparison of expression profiles of several fibroblast growth factor receptors in the mouse jejunum: suggestive evidence for a differential radioprotective effect among major FGF family members and the potency of FGF1
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Hagiwara, Akiko

× Hagiwara, Akiko

WEKO 486315

Hagiwara, Akiko

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Nakayama, Fumiaki

× Nakayama, Fumiaki

WEKO 486316

Nakayama, Fumiaki

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Motomura, Kaori

× Motomura, Kaori

WEKO 486317

Motomura, Kaori

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Asada, Masahiro

× Asada, Masahiro

WEKO 486318

Asada, Masahiro

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Suzuki, Masashi

× Suzuki, Masashi

WEKO 486319

Suzuki, Masashi

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Imamura, Toru

× Imamura, Toru

WEKO 486320

Imamura, Toru

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Akashi, Makoto

× Akashi, Makoto

WEKO 486321

Akashi, Makoto

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萩原 亜紀子

× 萩原 亜紀子

WEKO 486322

en 萩原 亜紀子

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中山 文明

× 中山 文明

WEKO 486323

en 中山 文明

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明石 真言

× 明石 真言

WEKO 486324

en 明石 真言

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抄録
内容記述タイプ Abstract
内容記述 Several members of the fibroblast growth factor (FGF) family have the potential to protect the intestine against the side-effects of radiation therapy. FGF1 is capable of signaling through all subtypes of FGF receptors (FGFRs), whereas FGF7 and FGF10 activate only epithelial-specific subtype, FGFR2IIIb (FGFR2b). The present study compared the protective activity of FGF1, FGF7, and FGF10 and examined the profiles of FGFR expression in the jejunum of BALB/c mice given total body irradiation (TBI) with gamma-rays. TBI caused drastic increases in FGFR1-4 transcript levels in the jejunum. However, FGFR2b protein temporarily decreased at 12 and 24 h after irradiation. FGF1 pretreatment minimized the number of apoptotic cells in jejunal crypts at 16 and 24 h after irradiation and increased crypt survival most effectively. In addition, pretreatment with FGF7 or FGF10 decreased FGFR1 transcript levels. The greater effectiveness of FGF1 to enhance crypt survival was also observed even when each FGF was administered 1 h after irradiation. These findings indicate that FGF1 is more potent than FGF7 or FGF10 for protection of the intestine against radiation exposure, and suggest that the profiles of FGFR expression in the intestine favor the FGF1 signaling pathway before and during the initial period after irradiation.
書誌情報 Radiation Research

巻 172, 号 1, p. 58-65, 発行日 2009-07
ISSN
収録物識別子タイプ ISSN
収録物識別子 0033-7587
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