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Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment.
https://repo.qst.go.jp/records/48222
https://repo.qst.go.jp/records/48222e33cf369-061c-48b7-9af4-81f9a886414b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-27 | |||||
| タイトル | ||||||
| タイトル | Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohtake, Makoto
× Ohtake, Makoto× Umemura, Masanari× Sato, Itaru× Akimoto, Taisuke× Oda, Kayoko× Nagasako, Akane× Kim, Jeong-Hwan× Fujita, Takayuki× Yokoyama, Utako× Nakayama, Tomohiro× Hoshino, Yujiro× Ishiba, Mai× Tokura, Susumu× Hara, Masakazu× Muramoto, Tomoya× Yamada, Sotoshi× Masuda, Takatsugu× Aoki, Ichio× Takemura, Yasushi× Murata, Hidetoshi× Eguchi, Haruki× Kawahara, Nobutaka× Ishikawa, Yoshihiro× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an alternating magnetic field (AMF). We showed that Fe(Salen) nanoparticles are useful for combined hyperthermia-chemotherapy of tongue cancer. Here, we have examined the effect of Fe(Salen) on human glioblastoma (GB). Fe(Salen) showed in vitro anti-tumor activity towards several human GB cell lines. It inhibited cell proliferation, and its apoptosis-inducing activity was greater than that of clinically used drugs. Fe(Salen) also showed in vivo anti-tumor activity in the mouse brain. We evaluated the drug distribution and systemic side effects of intracerebrally injected Fe(Salen) nanoparticles in rats. Further, to examine whether hyperthermia, which was induced by exposing Fe(Salen) nanoparticles to AMF, enhanced the intrinsic anti-tumor effect of Fe(Salen), we used a mouse model grafted with U251 cells on the left leg. Fe(Salen), BCNU, or normal saline was injected into the tumor in the presence or absence of AMF exposure. The combination of Fe(Salen) injection and AMF exposure showed a greater anti-tumor effect than did either Fe(Salen) or BCNU alone. Our results indicate that hyperthermia and chemotherapy with single-drug nanoparticles could be done for GB treatment. | |||||
| 書誌情報 |
Scientific reports 巻 7, p. 42783-1-42783-12, 発行日 2017-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28218292 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep42783 | |||||
