@article{oai:repo.qst.go.jp:00048222,
 author = {Ohtake, Makoto and Umemura, Masanari and Sato, Itaru and Akimoto, Taisuke and Oda, Kayoko and Nagasako, Akane and Kim, Jeong-Hwan and Fujita, Takayuki and Yokoyama, Utako and Nakayama, Tomohiro and Hoshino, Yujiro and Ishiba, Mai and Tokura, Susumu and Hara, Masakazu and Muramoto, Tomoya and Yamada, Sotoshi and Masuda, Takatsugu and Aoki, Ichio and Takemura, Yasushi and Murata, Hidetoshi and Eguchi, Haruki and Kawahara, Nobutaka and Ishikawa, Yoshihiro and 青木 伊知男},
 journal = {Scientific reports},
 month = {Feb},
 note = {We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an alternating magnetic field (AMF). We showed that Fe(Salen) nanoparticles are useful for combined hyperthermia-chemotherapy of tongue cancer. Here, we have examined the effect of Fe(Salen) on human glioblastoma (GB). Fe(Salen) showed in vitro anti-tumor activity towards several human GB cell lines. It inhibited cell proliferation, and its apoptosis-inducing activity was greater than that of clinically used drugs. Fe(Salen) also showed in vivo anti-tumor activity in the mouse brain. We evaluated the drug distribution and systemic side effects of intracerebrally injected Fe(Salen) nanoparticles in rats. Further, to examine whether hyperthermia, which was induced by exposing Fe(Salen) nanoparticles to AMF, enhanced the intrinsic anti-tumor effect of Fe(Salen), we used a mouse model grafted with U251 cells on the left leg. Fe(Salen), BCNU, or normal saline was injected into the tumor in the presence or absence of AMF exposure. The combination of Fe(Salen) injection and AMF exposure showed a greater anti-tumor effect than did either Fe(Salen) or BCNU alone. Our results indicate that hyperthermia and chemotherapy with single-drug nanoparticles could be done for GB treatment.},
 pages = {42783-1--42783-12},
 title = {Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment.},
 volume = {7},
 year = {2017}
}