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Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System
https://repo.qst.go.jp/records/48209
https://repo.qst.go.jp/records/4820901877448-ed1e-41ab-b6a6-4ee323543f9c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-26 | |||||
| タイトル | ||||||
| タイトル | Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Atanasova, Severina
× Atanasova, Severina× Nikolova, Biliana× Murayama, Shuhei× Stoyanova, Elena× Tsoneva, Iana× Zhelev, Zhivko× Aoki, Ichio× Bakalova, Rumiana× 村山 周平× Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ× 青木 伊知男× バカロバ ルミアナ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Nano-scale drug delivery systems (nano-DDS) are under active investigation. Nano-platforms are developed for specific administration of small molecules, drugs, genes, contrast agents [quantum dots (QDs] both in vivo and in vitro. Electroporation is a biophysical phenomenon which consists of the application of external electrical pulses across the cell membrane. The aim of this study was to research electro-assisted Colon 26 cell line internalization of QDs and QD-loaded nano-hydrogels (polymersomes) visualized by confocal microscopy and their influence on cell viability. Materials and Methods: The experiments were performed on the Colon 26 cancer cell line, using a confocal fluorescent imaging system and cell viability test. Results: Electroporation facilitated the delivery of nanoparticles in vivo. We demonstrated increased voltagedependent delivery of nanoparticles into cells after electrotreatment, without significant cell viability reduction. Conclusion: The delivery and retention of the polymersomes in vitro is a promising tool for future cancer treatment strategies and nanomedcine. | |||||
| 書誌情報 |
Anticancer Research 巻 36, 号 9, p. 4601-4606, 発行日 2016-09 |
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| 出版者 | ||||||
| 出版者 | International Institute of Anticancer Research (IIAR) | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21873/anticanres.11009 | |||||
