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Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas
https://repo.qst.go.jp/records/48144
https://repo.qst.go.jp/records/48144219264d8-2e67-4f5c-9b97-ce405ff4fa55
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-24 | |||||
| タイトル | ||||||
| タイトル | Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Showler, Kaye
× Showler, Kaye× Nishimura, Mayumi× Daino, Kazuhiro× Imaoka, Tatsuhiko× Nishimura, Yukiko× Morioka, Takamitsu× J., Blyth Benjamin× Kokubo, Toshiaki× Takabatake, Masaru× Fukuda, Maki× Moriyama, Hitomi× Kakinuma, Shizuko× Fukushi, Masahiro× Shimada, Yoshiya× ショウラー 恵× 西村 まゆみ× 臺野 和広× 今岡 達彦× 西村 由希子× 森岡 孝満× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 小久保 年章× 高畠 賢× 福田 真希× 森山 ひとみ× 柿沼 志津子× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The PI3K/AKT pathway is one of the most important signaling networks in human breast cancer and since it was potentially implicated in our preliminary investigations of radiation-induced rat mammary carcinomas, our aim here was to verify its role. We included mammary carcinomas induced by the chemical carcinogen 1-methyl-1-nitrosourea to determine if any changes were radiation-specific. Most carcinomas from both groups showed activation of the PI3K/AKT pathway, but phosphorylation of AKT1 was often heterogeneous and only in a minority of carcinoma cells. The negative pathway regulator Inpp4b was significantly down-regulated in both groups, compared to normal mammary tissue, and radiation-induced carcinomas also showed a significant decrease in Pten expression, while the chemical-induced carcinomas showed a decrease in Pik3r1 and Pdk1. Significant up-regulation of the positive regulators Erbb2 and Pik3ca was observed only in chemical-induced carcinomas. However, no genes showed clear correlations with AKT phosphorylation levels except in individual carcinomas. Only rare carcinomas showed mutations in PI3K/AKT pathway genes, yet these carcinomas did not exhibit stronger AKT phosphorylation. Thus, while AKT phosphorylation is a common feature of rat mammary carcinomas induced by radiation or a canonical chemical carcinogen, the mutation of key genes in the pathways or permanent changes to gene expression of particular signaling proteins do not explain the pathway activation in the advanced cancers. Although AKT signaling likely facilitates cancer development and growth in rat mammary carcinomas, it is unlikely that permanent disruption of the PI3K/AKT pathway genes is a major causal event in radiation carcinogenesis. | |||||
| 書誌情報 |
Journal of radiation research 巻 58, 号 2, p. 183-194, 発行日 2016-10 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 27738081 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrw097 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/jrr/article-lookup/doi/10.1093/jrr/rrw097 | |||||
| 関連名称 | https://academic.oup.com/jrr/article-lookup/doi/10.1093/jrr/rrw097 | |||||
