{"created":"2023-05-15T14:37:20.163267+00:00","id":48144,"links":{},"metadata":{"_buckets":{"deposit":"6bfa4af8-0c86-4ab5-9357-02c172a7b3ca"},"_deposit":{"created_by":1,"id":"48144","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48144"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048144","sets":["1"]},"author_link":["483468","483457","483471","483465","483473","483472","483456","483470","483469","483474","483475","483449","483453","483460","483454","483464","483461","483463","483458","483451","483466","483450","483459","483455","483452","483462","483467"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"194","bibliographicPageStart":"183","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The PI3K/AKT pathway is one of the most important signaling networks in human breast cancer and since it was potentially implicated in our preliminary investigations of radiation-induced rat mammary carcinomas, our aim here was to verify its role. We included mammary carcinomas induced by the chemical carcinogen 1-methyl-1-nitrosourea to determine if any changes were radiation-specific. Most carcinomas from both groups showed activation of the PI3K/AKT pathway, but phosphorylation of AKT1 was often heterogeneous and only in a minority of carcinoma cells. The negative pathway regulator Inpp4b was significantly down-regulated in both groups, compared to normal mammary tissue, and radiation-induced carcinomas also showed a significant decrease in Pten expression, while the chemical-induced carcinomas showed a decrease in Pik3r1 and Pdk1. Significant up-regulation of the positive regulators Erbb2 and Pik3ca was observed only in chemical-induced carcinomas. However, no genes showed clear correlations with AKT phosphorylation levels except in individual carcinomas. Only rare carcinomas showed mutations in PI3K/AKT pathway genes, yet these carcinomas did not exhibit stronger AKT phosphorylation. Thus, while AKT phosphorylation is a common feature of rat mammary carcinomas induced by radiation or a canonical chemical carcinogen, the mutation of key genes in the pathways or permanent changes to gene expression of particular signaling proteins do not explain the pathway activation in the advanced cancers. Although AKT signaling likely facilitates cancer development and growth in rat mammary carcinomas, it is unlikely that permanent disruption of the PI3K/AKT pathway genes is a major causal event in radiation carcinogenesis.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27738081","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rrw097","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://academic.oup.com/jrr/article-lookup/doi/10.1093/jrr/rrw097"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/jrr/article-lookup/doi/10.1093/jrr/rrw097","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata 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Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"483454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J., Blyth Benjamin"}],"nameIdentifiers":[{"nameIdentifier":"483455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokubo, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"483456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takabatake, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"483457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuda, Maki"}],"nameIdentifiers":[{"nameIdentifier":"483458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriyama, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"483459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"483460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, 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志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483475","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-24"},"publish_date":"2017-07-24","publish_status":"0","recid":"48144","relation_version_is_last":true,"title":["Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:31:26.684558+00:00"}