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Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four- dimensional computed tomography
https://repo.qst.go.jp/records/48095
https://repo.qst.go.jp/records/48095a0671a56-a466-44a9-b43b-3027b7d4d867
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-13 | |||||
| タイトル | ||||||
| タイトル | Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four- dimensional computed tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
川城, 壮平
× 川城, 壮平× 森, 慎一郎× 山田, 滋× 三木, 健太朗× 辻, 比呂志× 鎌田, 正× 川城 壮平× 森 慎一郎× 山田 滋× 三木 健太朗× 辻 比呂志× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Pancreatic cancer is a difficult to treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous in- tegrated boost (SIB) to increase tumour dose, sparing organs at risk (OARs). Methods: Using four-dimensional CT data of 12 patients, we delineated gross tumour volume and two clinical target volumes (CTVs). To consider beam range intra- fractional uncertainty, we calculated field-specific target volumes, from which two planning target volumes (PTVs) were generated. PTV1 would receive a planned dose of 55.2 Gy [relative biological effectiveness (RBE)-weighted absorbed dose] in 12 fractions, and PTV2 would receive an SIB dose up to 67.2 Gy (RBE). Dose assessments were conducted with regard to the targets and OARs. Results: CTV2 dose covering 95% of the volume (D95%) increased from 50.3 6 5.1 Gy (RBE) to 62.5 6 3.5 Gy (RBE) for a planned dose from 55.2Gy (RBE) to 67.2Gy (RBE). For 4 of 12 patients with a distance of $5mm between the tumour and the gastrointestinal tract, CTV2 D95% was $95% of planned dose at all dose levels. Conclusion: We quantified dose escalation with respiratory-gated C-PBS using SIB for pancreatic cancer and revealed that OAR dose was not affected to the same degree as the tumour dose. Advances in knowledge: A simulation study on respiratory- gated C-PBS with SIB for pancreatic cancer was per- formed. The results indicated the feasibility of dose escalation for pancreatic cancer, which should be con- firmed in clinical trials. |
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| 書誌情報 |
The British journal of radiology 巻 90, 号 1072, p. 790-799, 発行日 2017-03 |
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| 出版者 | ||||||
| 出版者 | British Institute of Radiology. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1748-880X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1259/bjr.20160790 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.birpublications.org/doi/full/10.1259/bjr.20160790 | |||||
| 関連名称 | http://www.birpublications.org/doi/full/10.1259/bjr.20160790 | |||||
