{"created":"2023-05-15T14:37:18.025154+00:00","id":48095,"links":{},"metadata":{"_buckets":{"deposit":"38ff348b-eb44-450c-b50f-0c4e5838620a"},"_deposit":{"created_by":1,"id":"48095","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48095"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048095","sets":["1"]},"author_link":["482947","482949","482955","482954","482958","482956","482957","482953","482951","482948","482950","482952"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1072","bibliographicPageEnd":"799","bibliographicPageStart":"790","bibliographicVolumeNumber":"90","bibliographic_titles":[{"bibliographic_title":"The British journal of radiology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Pancreatic cancer is a difficult to treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous in- tegrated boost (SIB) to increase tumour dose, sparing organs at risk (OARs).\nMethods: Using four-dimensional CT data of 12 patients, we delineated gross tumour volume and two clinical target volumes (CTVs). To consider beam range intra- fractional uncertainty, we calculated field-specific target volumes, from which two planning target volumes (PTVs) were generated. PTV1 would receive a planned dose of 55.2 Gy [relative biological effectiveness (RBE)-weighted absorbed dose] in 12 fractions, and PTV2 would receive an SIB dose up to 67.2 Gy (RBE). Dose assessments were conducted with regard to the targets and OARs.\nResults: CTV2 dose covering 95% of the volume (D95%) increased from 50.3 6 5.1 Gy (RBE) to 62.5 6 3.5 Gy (RBE) for a planned dose from 55.2Gy (RBE) to 67.2Gy (RBE). For 4 of 12 patients with a distance of $5mm between the tumour and the gastrointestinal tract, CTV2 D95% was $95% of planned dose at all dose levels.\nConclusion: We quantified dose escalation with respiratory-gated C-PBS using SIB for pancreatic cancer and revealed that OAR dose was not affected to the same degree as the tumour dose.\nAdvances in knowledge: A simulation study on respiratory- gated C-PBS with SIB for pancreatic cancer was per- formed. The results indicated the feasibility of dose escalation for pancreatic cancer, which should be con- firmed in clinical trials.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"British Institute of Radiology."}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1259/bjr.20160790","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.birpublications.org/doi/full/10.1259/bjr.20160790"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.birpublications.org/doi/full/10.1259/bjr.20160790","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1748-880X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川城, 壮平"}],"nameIdentifiers":[{"nameIdentifier":"482947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 慎一郎"}],"nameIdentifiers":[{"nameIdentifier":"482948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 滋"}],"nameIdentifiers":[{"nameIdentifier":"482949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三木, 健太朗"}],"nameIdentifiers":[{"nameIdentifier":"482950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 比呂志"}],"nameIdentifiers":[{"nameIdentifier":"482951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"482952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川城 壮平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 慎一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三木 健太朗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 比呂志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482958","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four- dimensional computed tomography","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four- dimensional computed tomography"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-13"},"publish_date":"2017-07-13","publish_status":"0","recid":"48095","relation_version_is_last":true,"title":["Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four- dimensional computed tomography"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:32:02.246279+00:00"}