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Amplification of glutathione-mediated oxidative stress by catalase in an aqueous solution at hyperthermal temperatures
https://repo.qst.go.jp/records/48075
https://repo.qst.go.jp/records/48075ff2737bc-b078-4890-95c8-c5c902ead13b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-11 | |||||
| タイトル | ||||||
| タイトル | Amplification of glutathione-mediated oxidative stress by catalase in an aqueous solution at hyperthermal temperatures | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ueno, Megumi
× Ueno, Megumi× Sekine, Emiko× Nyui, Minako× Nakanishi, Ikuo× Matsumoto, Ken-ichiro× 上野 恵美× 関根 絵美子× 乳井 美奈子× 中西 郁夫× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The glutathione (GSH)-mediated superoxide (O2•-) generation in an aqueous solution and relation of hydrogen peroxide (H2O2) and effect of catalase was investigated. GSH-induced O2•- generation in hyperthermal temperatures was measured by the nitroblue tetrazolium (NBT) mehod. Heating an aqueous solution containing GSH caused superoxide from dissolved O2. H2O2 was generated simultaneously in this reaction mixture probably from the hydroperoxy radical (HO2•), which is equilibrated with O2•- in an aqueous condition, and then H2O2 consumed O2•-. Coexisting catalase in the reaction mixture, as a result, could increase O2•- generation. The catalase-exaggerated extracellular O2•- generation could give a harmful effect to living cells. This GSH-induced oxidative stress can be a part of mechanisms of hyperthermia therapy. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 60, 号 2, p. 93-99, 発行日 2017-03 |
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| 出版者 | ||||||
| 出版者 | 日本酸化ストレス学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.16-28 | |||||
