@article{oai:repo.qst.go.jp:00048075,
 author = {Ueno, Megumi and Sekine, Emiko and Nyui, Minako and Nakanishi, Ikuo and Matsumoto, Ken-ichiro and 上野 恵美 and 関根 絵美子 and 乳井 美奈子 and 中西 郁夫 and 松本 謙一郎},
 issue = {2},
 journal = {Journal of Clinical Biochemistry and Nutrition},
 month = {Mar},
 note = {The glutathione (GSH)-mediated superoxide (O2•-) generation in an aqueous solution and relation of hydrogen peroxide (H2O2) and effect of catalase was investigated. GSH-induced O2•- generation in hyperthermal temperatures was measured by the nitroblue tetrazolium (NBT) mehod. Heating an aqueous solution containing GSH caused superoxide from dissolved O2. H2O2 was generated simultaneously in this reaction mixture probably from the hydroperoxy radical (HO2•), which is equilibrated with O2•- in an aqueous condition, and then H2O2 consumed O2•-. Coexisting catalase in the reaction mixture, as a result, could increase O2•- generation. The catalase-exaggerated extracellular O2•- generation could give a harmful effect to living cells. This GSH-induced oxidative stress can be a part of mechanisms of hyperthermia therapy.},
 pages = {93--99},
 title = {Amplification of glutathione-mediated oxidative stress by catalase in an aqueous solution at hyperthermal temperatures},
 volume = {60},
 year = {2017}
}