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PET quantification of the norepinephrine transporter in human brain with (S,S)-18F-FMeNER-D2.
https://repo.qst.go.jp/records/48073
https://repo.qst.go.jp/records/480739e7420fe-2069-40df-a5b4-a1bad22a8d13
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-02-16 | |||||
| タイトル | ||||||
| タイトル | PET quantification of the norepinephrine transporter in human brain with (S,S)-18F-FMeNER-D2. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Moriguchi, Sho
× Moriguchi, Sho× Kimura, Yasuyuki× Ichise, Masanori× Arakawa, Ryosuke× Takano, Harumasa× Seki, Chie× Ikoma, Yoko× Takahata, Keisuke× Nagashima, Tomohisa× Yamada, Makiko× Mimura, Masaru× Suhara, Tetsuya× Moriguchi, Sho× Kimura, Yasuyuki× Ichise, Masanori× Arakawa, Ryosuke× Takano, Harumasa× Seki, Chie× Ikoma, Yoko× Takahata, Keisuke× Nagashima, Tomohisa× Yamada, Makiko× Mimura, Masaru× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Norepinephrine transporter (NET) in the brain plays important roles in human cognition and the pathophysiology of psychiatric disorders. Two radioligands, (S,S)-(11)C-MRB and (S,S)-(18)F-FMeNER-D2, have been used for imaging NETs in the thalamus and midbrain (including locus coeruleus) using positron emission topography (PET) in humans. However, NET density in the equally important cerebral cortex has not been well quantified because of unfavorable kinetics with (S,S)-(11)C-MRB and defluorination with (S,S)-(18)F-FMeNER-D2, which can complicate NET quantification in the cerebral cortex adjacent to the skull containing defluorinated (18)F radioactivity. In this study, we have established analysis methods of quantification of NET density in the brain including cerebral cortex using (S,S)-(18)F-FMeNER-D2 PET. | |||||
| 書誌情報 |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 号 58, p. 1140-1145, 発行日 2016-12 |
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| 出版者 | ||||||
| 出版者 | Society of Nuclear Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0161-5505 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 27980046 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2967/jnumed.116.178913 | |||||
