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Efficiency of radiation-induced base lesion excision and the order of enzymatic treatment
https://repo.qst.go.jp/records/48015
https://repo.qst.go.jp/records/480150575f124-7776-496f-85e5-4ccf6cab6638
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-06-05 | |||||
| タイトル | ||||||
| タイトル | Efficiency of radiation-induced base lesion excision and the order of enzymatic treatment | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shiraishi, Iyo
× Shiraishi, Iyo× Shikazono, Naoya× Suzuki, Masao× Fuji, Kentaro× Yokoya, Akinari× 鹿園 直哉× 鈴木 雅雄× 藤井 健太郎× 横谷 明徳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To clarify whether initial base excision repair processes at clustered DNA damage sites comprising multiple base lesions affect subsequent excision processes, the formation of additional strand breaks by glycosylase and apurinic/apyrimidinic (AP) endonuclease was determined. We found that treatment order did not affect the final yields of additional SSB or DSB formed by glycosylase activity. This suggests that of the total damage, the fraction of clustered damage sites with a persistent base lesion dependent on the order of glycosylase treatment is insignificant if present. | |||||
| 書誌情報 |
International Journal of Radiation Biology 巻 93, 号 3, p. 295-302, 発行日 2016-11 |
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| 出版者 | ||||||
| 出版者 | Taylor and Francis | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553002.2017.1239849 | |||||
