@article{oai:repo.qst.go.jp:00048015, author = {Shiraishi, Iyo and Shikazono, Naoya and Suzuki, Masao and Fuji, Kentaro and Yokoya, Akinari and 鹿園 直哉 and 鈴木 雅雄 and 藤井 健太郎 and 横谷 明徳}, issue = {3}, journal = {International Journal of Radiation Biology}, month = {Nov}, note = {To clarify whether initial base excision repair processes at clustered DNA damage sites comprising multiple base lesions affect subsequent excision processes, the formation of additional strand breaks by glycosylase and apurinic/apyrimidinic (AP) endonuclease was determined. We found that treatment order did not affect the final yields of additional SSB or DSB formed by glycosylase activity. This suggests that of the total damage, the fraction of clustered damage sites with a persistent base lesion dependent on the order of glycosylase treatment is insignificant if present.}, pages = {295--302}, title = {Efficiency of radiation-induced base lesion excision and the order of enzymatic treatment}, volume = {93}, year = {2016} }