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Effect of Amifostine, a Radiation-Protecting Drug, on Oxygen Concentration in Tissue Measured by EPR Oximetry and Imaging
https://repo.qst.go.jp/records/47951
https://repo.qst.go.jp/records/479516371b750-529e-4d3c-a08a-28c747858b5c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-05-18 | |||||
| タイトル | ||||||
| タイトル | Effect of Amifostine, a Radiation-Protecting Drug, on Oxygen Concentration in Tissue Measured by EPR Oximetry and Imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ueno, Megumi
× Ueno, Megumi× Matsumoto, Shingo× Matsumoto, Atsuko× Manda, Sushma× Nakanishi, Ikuo× Matsumoto, Ken-ichiro× B., Mitchell James× C., Krishna Murali× Anzai, Kazunori× 上野 恵美× 松本 厚子× Ｍａｎｄａ Ｓｕｓｈｍａ× 中西 郁夫× 松本 謙一郎× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effect of amifostine, a radiation-protecting drug, on muscle tissue partial pressure of oxygen (pO2) was investigated by electron paramagnetic resonance (EPR) spectroscopy and imaging. When amifostine was administered intraperitoneally or intravenously to mice, the linewidth of the EPR spectra of the lithium octa-n-butoxy-substituted naphthalocyanine (LiNc-BuO) implanted in the mouse leg muscle decreased. EPR oximetry using a LiNc-BuO probe and EPR oxygen mapping using a triarylmethyl-type probe was useful to quantify pO2 in the tissues of living mice. The result of EPR oximetric imaging showed that administration of amifostine can decrease pO2 in the muscle and also tumor tissues. This finding suggests that lowering pO2 in tissues might contribute in part to the radioprotection of amifostine. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 60, 号 3, p. 151-155, 発行日 2017-05 |
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| 出版者 | ||||||
| 出版者 | 日本酸化ストレス学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
