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PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.
https://repo.qst.go.jp/records/47780
https://repo.qst.go.jp/records/4778015385d1b-489f-4bcb-9ae9-e6f58a2319fc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-25 | |||||
| タイトル | ||||||
| タイトル | PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nagai, Yuji
× Nagai, Yuji× Kikuchi, Erika× Lerchner, Walter× Inoue, Ken-ichi× Ji, Bin× A.G., Eldridge Mark× Kaneko, Hiroyuki× Kimura, Yasuyuki× Oh-Nishi, Arata× Hori, Yukiko× Kato, Yoko× Hirabayashi, Toshiyuki× Fujimoto, Atsushi× Kumata, Katsushi× Zhang, Ming-Rong× Aoki, Ichio× Suhara, Tetsuya× Higuchi, Makoto× Takada, Masahiko× J., Richmond Barry× Minamimoto, Takafumi× 永井 裕司× 菊池 瑛理佳× 季 斌× 金子 博之× 木村 泰之× 堀 由紀子× 加藤 陽子× 平林 敏行× 藤本 淳× 熊田 勝志× 張 明栄× 青木 伊知男× 須原 哲也× 樋口 真人× 南本 敬史 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The rostromedial caudate (rmCD) of primates is thought to contribute to reward value processing, but a causal relationship has not been established. Here we use an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drug) to repeatedly and non-invasively inactivate rmCD of macaque monkeys. We inject an adeno-associated viral vector expressing the inhibitory DREADD, hM4Di, into the rmCD bilaterally. To visualize DREADD expression in vivo, we develop a non-invasive imaging method using positron emission tomography (PET). PET imaging provides information critical for successful chemogenetic silencing during experiments, in this case the location and level of hM4Di expression, and the relationship between agonist dose and hM4Di receptor occupancy. Here we demonstrate that inactivating bilateral rmCD through activation of hM4Di produces a significant and reproducible loss of sensitivity to reward value in monkeys. Thus, the rmCD is involved in making normal judgments about the value of reward. | |||||
| 書誌情報 |
Nature Communications 巻 7, p. 13605-1-13605-8, 発行日 2016-12 |
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| 出版者 | ||||||
| 出版者 | Nature Pub. Group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 27922009 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/ncomms13605 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/articles/ncomms13605 | |||||
| 関連名称 | http://www.nature.com/articles/ncomms13605 | |||||
