@article{oai:repo.qst.go.jp:00047780,
 author = {Nagai, Yuji and Kikuchi, Erika and Lerchner, Walter and Inoue, Ken-ichi and Ji, Bin and A.G., Eldridge Mark and Kaneko, Hiroyuki and Kimura, Yasuyuki and Oh-Nishi, Arata and Hori, Yukiko and Kato, Yoko and Hirabayashi, Toshiyuki and Fujimoto, Atsushi and Kumata, Katsushi and Zhang, Ming-Rong and Aoki, Ichio and Suhara, Tetsuya and Higuchi, Makoto and Takada, Masahiko and J., Richmond Barry and Minamimoto, Takafumi and 永井 裕司 and 菊池 瑛理佳 and 季 斌 and 金子 博之 and 木村 泰之 and 堀 由紀子 and 加藤 陽子 and 平林 敏行 and 藤本 淳 and 熊田 勝志 and 張 明栄 and 青木 伊知男 and 須原 哲也 and 樋口 真人 and 南本 敬史},
 journal = {Nature Communications},
 month = {Dec},
 note = {The rostromedial caudate (rmCD) of primates is thought to contribute to reward value processing, but a causal relationship has not been established. Here we use an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drug) to repeatedly and non-invasively inactivate rmCD of macaque monkeys. We inject an adeno-associated viral vector expressing the inhibitory DREADD, hM4Di, into the rmCD bilaterally. To visualize DREADD expression in vivo, we develop a non-invasive imaging method using positron emission tomography (PET). PET imaging provides information critical for successful chemogenetic silencing during experiments, in this case the location and level of hM4Di expression, and the relationship between agonist dose and hM4Di receptor occupancy. Here we demonstrate that inactivating bilateral rmCD through activation of hM4Di produces a significant and reproducible loss of sensitivity to reward value in monkeys. Thus, the rmCD is involved in making normal judgments about the value of reward.},
 pages = {13605-1--13605-8},
 title = {PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.},
 volume = {7},
 year = {2016}
}