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Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope.
https://repo.qst.go.jp/records/47762
https://repo.qst.go.jp/records/477622af3b903-c988-4f99-88a7-274421b99402
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-25 | |||||
| タイトル | ||||||
| タイトル | Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Takuwa, Hiroyuki× Tajima, Yosuke× Kawaguchi, Hiroshi× Urushihata, Takuya× Taniguchi, Junko× Ikoma, Yoko× Seki, Chie× Ibaraki, Masanobu× Masamoto, Kazuto× Kanno, Iwao× 伊藤 浩× 田桑 弘之× 川口 拓之× 漆畑 拓弥× 生駒 洋子× 関 千江× 茨木 正信× 正本 和人× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The relation between cerebral blood flow (CBF) and cerebral oxygen extraction fraction (OEF) can be expressed using the effective diffusivity for oxygen in the capillary bed (D) as OEF = 1 - exp(-D/CBF). The D value is proportional to the microvessel blood volume. In this study, changes in D during neural activation and deactivation were estimated from changes in capillary and arteriole diameter measured by two-photon microscopy in awake mice. Capillary and arteriole vessel diameter in the somatosensory cortex and cerebellum were measured under neural activation (sensory stimulation) and neural deactivation [crossed cerebellar diaschisis (CCD)], respectively. Percentage changes in D during sensory stimulation and CCD were 10.3 ± 7.3 and -17.5 ± 5.3 % for capillary diameter of <6 μm, respectively. These values were closest to the percentage changes in D calculated from previously reported human positron emission tomography data. This may indicate that thinner capillaries might play the greatest role in oxygen transport from blood to brain tissue. | |||||
| 書誌情報 |
The journal of physiological sciences : JPS 巻 67, 号 2, p. 325-330, 発行日 2016-06 |
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| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 27344668 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12576-016-0466-z | |||||
